Ovarian cancer (OC) is one of the most lethal gynecologic malignancies globally. In spite of
positive responses to initial therapy, the overall survival rates of OC patients remain poor …

Epithelial ovarian cancer is the most lethal gynaecological cancer with the majority of
patients succumbing to chemotherapy-resistant disease. Unravelling the mechanisms of …

Simple Summary When tumors become resistant to chemotherapeutics, alternative
treatment strategies must be explored. Gene targeting provides a personalized and …

Simple Summary Ovarian cancer is the leading cause of death by a gynecological tumor,
mainly due to its common detection in advanced stages and to its high resistance to …

Ovarian cancer (OC) is one of the most common malignant tumors in women. OC is
associated with the activation of oncogenes, the inactivation of tumor suppressor genes, and …

Epigenetic changes in tumours are associated not only with cancer development and
progression, but also with resistance to chemotherapy. Aberrant DNA methylation at CpG …

Epithelial ovarian cancer (EOC) is one of the most aggressive forms of gynaecological
malignancies. Survival rates for women diagnosed with OC remain poor as most patients …

Ovarian cancer is a major cause of death among gynecological cancers and its etiology is
still unclear. Currently, the two principle obstacles in treating this life threatening disease are …

Epithelial ovarian cancer (EOC) is the most difficult cancer to cure in gynecological
malignancy. Over 70% of patients respond to chemotherapy initially, but the majority will …

Background Cisplatin and carboplatin are the primary first-line therapies for the treatment of
ovarian cancer. However, resistance to these platinum-based drugs occurs in the large …