Aberrant epigenetic reprogramming is known to be a major cause of inefficient somatic cell
nuclear transfer (SCNT) in pigs, and use of epigenetic modification agents, such as DNA …

Aberration in DNA methylation is believed to be one of the major causes of abnormal gene
expression and inefficiency of somatic cell nuclear transfer (SCNT). RG108, a non …

Aberrant DNA methylation reduces the developmental competence of mammalian somatic
cell nuclear transfer (SCNT) embryos. Thus, hypomethylation-associated drugs are …

Incomplete DNA methylation reprogramming in cloned embryos leads to poor cloning
efficiency. Epigenetic modification agents can improve genomic methylation reprogramming …

Incomplete DNA methylation reprogramming in cloned embryos leads to low cloning
efficiency. Our previous studies showed that the epigenetic modification agents 5-aza-2' …

Background/Aims: DNA methylation and histone modifications are essential epigenetic
marks that can significantly affect the mammalian somatic cell nuclear transfer (SCNT) …

DNA methylation reprogramming, regulated by DNA methylation and demethylation related
genes, is essential for early embryo development; however, it is incomplete in cloned …

Somatic cell nuclear transfer (SCNT) in mammalian cloning currently remains inefficient.
Incomplete or erroneous epigenetic reprogramming of specialized donor somatic nuclear …

Nuclear reprogramming induced by somatic cell nuclear transfer is an inefficient process,
and donor cell DNA methylation status is thought to be a major factor affecting cloning …

Apoptosis and incomplete DNA methylation reprogramming in cloned embryos reduce
cloning efficiency. 5-aza-2′-deoxycytidine (5-aza-dC) is proven to regulate apoptosis and …