Epigenetic mechanisms play an important role in oogenesis and early embryo development
in mammals. Dimethyl sulfoxide (DMSO) is frequently used as a solvent in biological studies …

Somatic cell nuclear transfer in mammalian cloning suffers from a faulty epigenetic
reprogramming, which is believed to cause developmental failures in cloned embryos …

This study investigated whether treating fetal fibroblast cells (donor cells) with epigenetic
modification-inducing drugs could improve the development of porcine cloned embryos …

The efficiency to produce offspring by somatic cell nuclear transfer (SCNT) is low. It has
been showed that treatment of donor cells with Xenopus oocyte extract increased live births …

For the successful production of cloned animals by somatic cell nuclear transfer (NT), the
epigenetic status of the differentiated donor cell is reversed to an embryonic totipotent status …

Zygotic epigenetic reprogramming is the major initial event in embryo development to
acquire a totipotent potential. However, the patterns of epigenetic modifications in bovine …

Efficient epigenetic reprogramming is crucial for the in vitro development of mammalian
somatic cell nuclear transfer (SCNT) embryos. The aberrant levels of histone H3 lysine 9 …

Somatic cell nuclear transfer (SCNT) derived embryos suffer from abnormal epigenetic
reprogramming, which handicaps pre-and postimplantation development. It was …

Aberrant patterns of DNA methylation are consistent events in SCNT derived embryos and
mechanistically are believed to be related to abnormal development. While some epigenetic …

Epigenetic status of the genome of a donor nucleus has an important effect on the
developmental potential of cloned embryos produced by somatic cell nuclear transfer …