Chemotherapy with a single chemotherapeutic agent or a combined chemotherapeutic
regimen is the clinically standardized treatment for almost all human cancers. Upregulated …

Cancer is a major cause of death worldwide despite significant advances in surgery and
biology. Several recent studies have suggested that there is a close connection between …

Abstract Cyclooxygenase‐2 (COX‐2) is frequently expressed in many types of cancers
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …

Abstract Cyclooxygenase-2 (COX-2), an inducible form of the enzyme that catalyzes the first
step in the synthesis of prostanoids, is associated with inflammatory diseases and …

Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic
acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed …

The recent marketing of two selective cyclooxygenase-2 (COX-2) inhibitors, celecoxib and
rofecoxib is remarkable considering that COX-2 was only discovered eight years ago as a …

It is well admitted that the link between chronic inflammation and cancer involves cytokines
and mediators of inflammatory pathways, which act during the different steps of …

Despite recent improvements in chemotherapy and radiation therapy in cancer management
with the addition of biological agents, novel treatment approaches are needed to further …

Cyclooxygenase-2 (COX-2) overexpression is seen in many malignancies including lung
cancer. Elevated tumor prostaglandin E2 (PGE2), a major COX-2 metabolite, levels have …

Increased prostaglandin (PG) production is associated with many inflammatory
pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes …