Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …

The cyclooxygenase-2 (COX-2) protein is highly expressed in a variety of human cancers
and has been reported to promote tumor growth. Non-steroidal anti-inflammatory drugs such …

Abstract Cyclooxygenase‐2 (COX‐2) is an enzyme involved in tumorigenesis, and inhibitors
of the enzyme are increasingly used as adjuvant modulators in anticancer therapies due to …

There is much interest in the potential use of Cox-2 selective inhibitors in combination with
other cancer therapeutics. Malignancies of hematopoietic and non-hematopoietic origin …

Cyclooxygenase-2 (COX-2) is being intensively evaluated as a pharmacologic target for
both the prevention and treatment of cancer. Aberrant COX-2 expression was initially …

Cyclooxygenase-2 (COX-2) overexpression is seen in many malignancies including lung
cancer. In non-small cell lung cancer (NSCLC), COX-2 is overexpressed in most …

Cyclooxygenase (COX) inhibitors are being developed as potential agents for the
prevention and treatment of cancer after a century of widespread use for inflammation, fever …

Purpose: Our previous study revealed that simultaneously targeting epidermal growth factor
receptor (EGFR) tyrosine kinase and cyclooxygenase-2 (COX-2) additively or synergistically …

Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic
acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of …

Cyclooxygenase-2 (COX-2) is an enzyme induced by a variety of factors including tumor
promoters, cytokines, growth factors and hypoxia. It is involved in the metabolic conversion …