Reactivation of telomerase is a critical step in the development of hepatocellular carcinoma
(HCC). Here we identified the frequency of mutations in telomerase reverse transcriptase …

Simple Summary Telomerase reverse transcriptase (TERT) mutations are the most frequent
genetic alterations in hepatocellular carcinoma (HCC). However, integrative analysis studies …

Telomerase reverse transcriptase (TERT) promoter mutations are frequently observed in
hepatocellular carcinoma (HCC); however, the impact of TERT promoter mutations (TPMs) …

Telomerase activation via induction of the catalytic component telomerase reverse
transcriptase (TERT) plays essential roles in malignant transformation. TERT promoter …

Through several studies exploiting next-generation sequencing, we are obtaining a clearer
picture of the complex genetic and molecular landscape of hepatocellular carcinoma (HCC) …

Simple Summary Activating mutations in the promoter region of TERT (TERTp) gene are
frequently observed in low-and high-grade dysplastic nodules and defined as early events …

Promoter mutations in telomerase reverse transcriptase (TERT) and telomere length have
been studied in various tumors. In the present study, the frequency and clinical …

Background: Mutations in the human telomerase reverse transcriptase (hTERT) gene
promoter have been reported in hepatocellular carcinoma (HCC); however, analyses of …

Worldwide, there are approximately 750,000 new cases of hepatocellular carcinoma (HCC)
each year [1]. Although HCC has the 5th highest incidence rate in men and 9th highest …

Background & Aims Telomerase activation is the earliest event in hepatocellular carcinoma
(HCC) development. Thus, we aimed to elucidate the role of telomere length maintenance …