BACKGROUND & AIMS: The maintenance of the telomere to a certain length is considered
to be vital for cellular immortality. Recently, the presence of telomerase, an enzyme that …

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide.
However, there is no effective treatment for HCC. It has been shown that sustained activation …

Human telomerase reverse transcriptase (hTERT) has been identified as the catalytic
subunit of human telomerase. To clarify the clinical significance of hTERT mRNA in …

The telomeric repeat-binding factor 1 (TRF1), TRF2, and the TRF1-interacting nuclear
protein 2 (TIN2) are involved in telomere maintenance. We describe the regulation of …

Telomerase activity and telomere elongation are essential conditions for the unlimited
proliferation of neoplastic cells. Point mutations in the core promoter region of the …

Genetic association analysis and functional analysis have suggested that telomerase
reverse transcriptase (TERT) gene affects the predisposition to various tumors. In this study …

Backgrounds/Aims: The maintenance of telomere with telomerase reactivation, vital for
carcinogenesis, was studied in human multistep hepatocarcinogenesis for the …

Background: Expression of telomerase activity and stabilization of telomeres are
concomitant with attainment of immortality in tumor cells. Telomerase activity levels in …

Objectives: Liver cancer is the most common neoplasm and the most common cause of
cancer death within the world. Early detection of hepatocellular carcinoma (HCC) will …

BACKGROUND Despite the recent discovery of interchromosomal telomere length variation,
a role for heterogeneity in telomere maintenance has yet to be established. This study …