The locus coeruleus (LC) is a brainstem region involved in regulating pain. Chronic pain is
common in older adulthood, but no studies have examined its association with the LC in …

Animal studies have suggested essential links between chronic pain and the locus
coeruleus (LC), a brainstem region important for attention, but also pain and cognitive …

The locus coeruleus (LC), a major origin of noradrenergic projections in the central nervous
system (CNS), may serve a critical role in the pathogenesis of neurodegenerative disorders …

Background Post-mortem studies suggest neurodegeneration of norepinephrine projections
from the locus coeruleus (LC) may be associated with both major depressive disorder and …

The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a
lot of attention because of its emerging role in cognitive and psychiatric disorders. Although …

The brainstem locus coeruleus (LC) influences a broad range of brain processes, including
cognition. The so-called LC contrast is an accepted marker of the integrity of the LC that …

Background Neuropathological studies have pointed to the importance of
neurodegeneration in the locus coeruleus (LC) as a possible early biomarker of Alzheimer's …

Late-life depression (LLD) is a risk factor for age-dependent cognitive deterioration.
Norepinephrine-related degeneration in the locus coeruleus (LC) may explain this link. To …

Background The locus coeruleus (LC) is a bilateral nucleus located in the dorsal pontine
tegmentum and is the major source of noradrenaline (NA), which plays a key role in …

Introduction The locus coeruleus (LC) undergoes extensive neurodegeneration in early
Alzheimer's disease (AD). The LC is implicated in regulating the sleep–wake cycle …