Endothelin (ET) is a potent vasoconstrictive peptide that was isolated initially from the
conditioned medium of cultured endothelial cells. In 1988, details of the isolation and …

Endothelin (ET) is a potent vasoconstrictive peptide initially found in the conditioned medium
of cultured endothelial cells (1). It comprises 21 amino acid residues including four cysteine …

Endothelin (ET)-1, an endothelium-derived peptide, is the most potent vasoconstrictor agent
described to date. ET-1 also has positive inotropic and chronotropic effects in the heart and …

In 1988, Yanagisawa et al. reported the presence of a potent peptide from the supernatant of
porcine endothelial cells. This was later named endothelin‐1 (ET‐1) and was found to …

Endothelin-1 (ET-1) is a potent vasoconstrictive peptide produced by endothelial cells of
blood vessels. This peptide has quite a unique structure and pharmacological properties. ET …

Since the discovery of the most potent vasoconstrictor peptide, endothelin, in 1988,
explosive investigations have rapidly clarified much of the basic pharmacological …

Endothelin (ET) is a potent vasoconstrictor peptide that is generated via unique processing
of a low activity precursor, big ET-1 by endothelin converting enzymes (ECEs). ET has a …

Abstract The endothelins (ET) are 21-amino-acid peptides produced by endothelial cells
and many other tissues [1]. Three isoforms of ET have been characterized (ET-1, 2 and 3) …

Endothelins (ET) are a family of peptides with potent biological properties. Endothelial cells
produce exclusively ET-1 while other tissues produce ET-2 and ET-3. The production of ET …

In 1988, Yanagisawa and colleagues' isolated from the culture medium of vascular
endothelial cells a novel 21 amino-acid pep tide, endothelln, which is the most potent …