Identification of lung innervating sensory neurons and their target specificity

Y Su, J Barr, A Jaquish, J Xu… - American Journal of …, 2022 - journals.physiology.org
Known as the gas exchange organ, the lung is also critical for responding to the aerosol
environment in part through interaction with the nervous system. The diversity and specificity …

Sensory nerves in lung and airways

LY Lee, J Yu - Comprehensive Physiology, 2011 - Wiley Online Library
Sensory nerves innervating the lung and airways play an important role in regulating various
cardiopulmonary functions and maintaining homeostasis under both healthy and disease …

Transcriptional profiling of individual airway projecting vagal sensory neurons

SB Mazzone, L Tian, AAK Moe, MW Trewella… - Molecular …, 2020 - Springer
Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are
essential for monitoring the physical and chemical environment of the airways and lungs …

Mapping of the sensory innervation of the mouse lung by specific vagal and dorsal root ganglion neuronal subsets

SH Kim, MJ Patil, SH Hadley, PK Bahia, SG Butler… - eneuro, 2022 - eneuro.org
The airways are densely innervated by sensory afferent nerves, whose activation regulates
respiration and triggers defensive reflexes (eg, cough, bronchospasm). Airway innervation is …

Vagal afferent innervation of the airways in health and disease

SB Mazzone, BJ Undem - Physiological reviews, 2016 - journals.physiology.org
Vagal sensory neurons constitute the major afferent supply to the airways and lungs.
Subsets of afferents are defined by their embryological origin, molecular profile …

Sensory receptors in the airways: neurochemical coding of smooth muscle-associated airway receptors and pulmonary neuroepithelial body innervation

I Brouns, I De Proost, I Pintelon, JP Timmermans… - Autonomic …, 2006 - Elsevier
Mainly due to the lack of conclusive morphological data, correlation between functionally
and morphologically defined lung receptors has so far been unsatisfactory. In the present …

Identification of neurotransmitters and co-localization of transmitters in brainstem respiratory neurons

RL Stornetta - Respiratory physiology & neurobiology, 2008 - Elsevier
Identifying the major ionotropic neurotransmitter in a respiratory neuron is of critical
importance in determining how the neuron fits into the respiratory system, whether in …

Recent advances and contraversies on the role of pulmonary neuroepithelial bodies as airway sensors

E Cutz, J Pan, H Yeger, NJ Domnik, JT Fisher - Seminars in cell & …, 2013 - Elsevier
Pulmonary neuroepithelial bodies are polymodal sensors widely distributed within the
airway mucosa of mammals and other species. Neuroepithelial body cells store and most …

Evidence for a role of neuroepithelial bodies as complex airway sensors: comparison with smooth muscle-associated airway receptors

D Adriaensen, I Brouns, I Pintelon… - Journal of Applied …, 2006 - journals.physiology.org
The epithelium of intrapulmonary airways in many species harbors diffusely spread
innervated groups of neuroendocrine cells, called neuroepithelial bodies (NEBs). Data on …

[HTML][HTML] Vagal sensory neuron subtypes that differentially control breathing

RB Chang, DE Strochlic, EK Williams, BD Umans… - Cell, 2015 - cell.com
Breathing is essential for survival and under precise neural control. The vagus nerve is a
major conduit between lung and brain required for normal respiration. Here, we identify two …