Prenatal stress induces translational disruption associated with myelination deficits

GK Crombie, HK Palliser, JC Shaw, BA Hanley… - Dev. Neurosci, 2023 - karger.com
Disruptions to neurodevelopment are known to be linked to behavioral disorders in
childhood and into adulthood. The fetal brain is extremely vulnerable to stimuli that alter …

Maternal stress in pregnancy affects myelination and neurosteroid regulatory pathways in the guinea pig cerebellum

GA Bennett, HK Palliser, JC Shaw, KL Palazzi… - Stress, 2017 - Taylor & Francis
Prenatal stress predisposes offspring to behavioral pathologies. These may be attributed to
effects on cerebellar neurosteroids and GABAergic inhibitory signaling, which can be linked …

Neurosteroid-based intervention using Ganaxolone and Emapunil for improving stress-induced myelination deficits and neurobehavioural disorders

GK Crombie, HK Palliser, JC Shaw… - …, 2021 - Elsevier
Background Prenatal stress is associated with long-term disturbances in white matter
development and behaviour in children, such as attention deficit hyperactivity disorder …

Evaluating changes in GABAergic and glutamatergic pathways in early life following prenatal stress and postnatal neurosteroid supplementation

GK Crombie, HK Palliser, JC Shaw… - …, 2022 - Elsevier
Background A correct balance of activity of the GABA and glutamate systems is vital for
optimal neurodevelopment and general CNS function, and the dysregulation of this balance …

[HTML][HTML] Impaired oligodendrocyte development following preterm birth: promoting GABAergic action to improve outcomes

JC Shaw, GK Crombie, HK Palliser, JJ Hirst - Frontiers in pediatrics, 2021 - frontiersin.org
Preterm birth is associated with poor long-term neurodevelopmental and behavioral
outcomes, even in the absence of obvious brain injury at the time of birth. In particular …

Effects of prenatal stress on behavioural and neurodevelopmental outcomes are altered by maternal separation in the neonatal period

GK Crombie, HK Palliser, JC Shaw… - …, 2021 - Elsevier
Background Chronic psychosocial stress during pregnancy and/or after birth, and the
associated elevation in cortisol, is linked with the onset of behavioural disorders in …

Effects of prenatal stress on fetal neurodevelopment and responses to maternal neurosteroid treatment in guinea pigs

GA Bennett, HK Palliser, B Saxby, DW Walker… - Developmental …, 2013 - karger.com
Background: Maternal psychosocial stress during pregnancy is associated with adverse
neonatal outcomes. These outcomes result from changes in fetal brain development and …

The role of redox dysregulation in the effects of prenatal stress on embryonic interneuron migration

J Bittle, EC Menezes, ML McCormick, DR Spitz… - Cerebral …, 2019 - academic.oup.com
Maternal stress during pregnancy is associated with increased risk of psychiatric disorders
in offspring, but embryonic brain mechanisms disrupted by prenatal stress are not fully …

Prenatal stress and increased susceptibility to anxiety-like behaviors: role of neuroinflammation and balance between GABAergic and glutamatergic transmission

S Roshan-Milani, B Seyyedabadi, E Saboory… - Stress, 2021 - Taylor & Francis
Neuroplasticity during the prenatal period allows neurons to regenerate anatomically and
functionally for re-programming the brain development. During this critical period of fetal …

Neurodevelopmental consequences of maternal distress: what do we really know?

C Schuurmans, DM Kurrasch - Clinical genetics, 2013 - Wiley Online Library
Schuurmans C, Kurrasch DM. Neurodevelopmental consequences of maternal distress:
what do we really know? A simple internet search of 'maternal stress and pregnancy'turns up …