The blood–brain barrier (BBB) plays critical roles in the maintenance of central nervous
system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases …

In vascular dementia (VaD) and Alzheimer's disease (AD), cerebral hypoperfusion and
blood‐brain barrier (BBB) leakiness contribute to brain damage. In this study, we have …

Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) are
debilitating conditions that are highly associated with aging populations, especially those …

Reduced cerebral blood flow in Alzheimer's disease (AD) may occur in early AD, which
contributes to the pathogenesis and/or pathological progression of AD. Reversing this deficit …

Increasing evidence implicates endothelial dysfunction in the pathogenesis of Alzheimer's
disease (AD). Nitric oxide (NO) derived from endothelial NO synthase (eNOS) is essential in …

Cardiovascular risk factors, especially hypertension, are also major risk factors for
Alzheimer's disease (AD). To elucidate the underlying vascular origin of neurodegenerative …

Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …

Vascular dysregulation and cholinergic basal forebrain degeneration are both early
pathological events in the development of Alzheimer's disease (AD). Acetylcholine …

Vascular changes are thought to contribute to the development of Alzheimer's disease, and
both cerebral blood flow and its responses during neural activation are reduced before …

Alzheimer's disease (AD) is the most common type of dementia frequently responsible for
cognitive decline in the elderly. The etiology and molecular mechanism of AD pathogenesis …