Chronic HCV (CHC) infection is the only chronic viral infection for which curative treatments
have been discovered. These direct acting antiviral (DAA) agents target specific steps in the …

The immune response in patients chronically infected with HCV plays a unique role during
the infection because of its potential to contribute not only to viral clearance and, in some …

Recent introduction of all-oral direct-acting antiviral (DAA) treatment has revolutionized care
of patients with chronic hepatitis C virus infection. Because patients with different liver …

Worldwide, 71 million individuals are chronically infected with Hepatitis C Virus (HCV).
Chronic HCV infection can lead to potentially fatal outcomes including liver cirrhosis and …

Hepatitis C virus (HCV) is a small positive-sense, single-stranded RNA virus, the causal
organism for chronic hepatitis. Chronic hepatitis leads to inflammation of liver, causing …

Chronic viral infections cause deterioration of our immune system. However, since persistent
infections rarely can be eliminated, the reinvigoration capacity of an exhausted immune …

A functional adaptive immune response is the major determinant for clearance of hepatitis C
virus (HCV) infection. However, in the majority of patients, this response fails and persistent …

Hepatitis C virus (HCV) has spread worldwide, and it is responsible for potentially severe
chronic liver disease and primary liver cancer. Chronic infection remains for life if not …

ACCEPTED worldwide, 1.5 million new annual cases and 290,000 deaths each year from
advanced liver diseases, such as cirrhosis and cancer.[1] In response, the World Health …

Hepatitis C virus (HCV) remains a public health problem of global importance, even in the
era of potent directly-acting antiviral drugs. In this chapter, I discuss immune responses to …