Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly
reduces lifespan, and its overexpression extends it and protects against various pathological …

Klotho is a novel renoprotective anti-aging protein available in membrane-bound or soluble
form. Klotho is expressed in brain, pancreas, and other solid organs but shows highest …

OBJECTIVE Klotho is an antiaging hormone present in the kidney that extends the lifespan,
regulates kidney function, and modulates cellular responses to oxidative stress. We …

Klotho in health and disease : Current Opinion in Nephrology and Hypertension Klotho in
health and disease : Current Opinion in Nephrology and Hypertension Log in or Register …

Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of
Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein …

Klotho is a membrane‐bound or soluble antiaging protein, whose protective activity is
essential for a proper function of many organs. In 1997, an accidental insertion of a …

Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term
loss of kidney function. The progression of CKD has repercussions for other organs, leading …

Klotho is a new anti-aging gene. Genetic mutation of klotho causes multiple premature aging-
like phenotypes and strikingly shortens lifespan. Overexpression of the klotho gene in mice …

Through alternative splicing, Klotho protein exists both as a secreted and a membrane form
whose extracellular domain could be shed from the cell surface by secretases and released …

The Klotho gene has been identified as an aging suppressor gene that encodes a
transmembrane protein, which is expressed primarily in renal tubules. There are 2 forms of …