Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8+ T cells
F Winkler, AV Hipp, C Ramirez, B Martin, M Villa… - Gut, 2023 - gut.bmj.com
Objective Exhausted T cells with limited effector function are enriched in chronic hepatitis B
and C virus (HBV and HCV) infection. Metabolic regulation contributes to exhaustion, but it …
and C virus (HBV and HCV) infection. Metabolic regulation contributes to exhaustion, but it …
[HTML][HTML] Functional reconstitution of HBV-specific CD8 T cells by in vitro polyphenol treatment in chronic hepatitis B
G Acerbi, I Montali, GD Ferrigno, V Barili… - Journal of …, 2021 - Elsevier
Background & Aims In chronic HBV infection, mitochondrial functions and proteostasis are
dysregulated in exhausted HBV-specific CD8 T cells. To better characterise the potential …
dysregulated in exhausted HBV-specific CD8 T cells. To better characterise the potential …
Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B
Hepatitis B virus (HBV)-specific CD8 T cells are functionally exhausted in chronic hepatitis B
infection, and this condition can be corrected only partially through the modulation of …
infection, and this condition can be corrected only partially through the modulation of …
[PDF][PDF] Distinct metabolic requirements of exhausted and functional virus-specific CD8 T cells in the same host
A Schurich, LJ Pallett, D Jajbhay, J Wijngaarden… - Cell reports, 2016 - cell.com
T cells undergo profound metabolic changes to meet the increased energy demands of
maintaining an antiviral response. We postulated that differences in metabolic …
maintaining an antiviral response. We postulated that differences in metabolic …
[HTML][HTML] Unraveling the multifaceted nature of CD8 T cell exhaustion provides the molecular basis for therapeutic T cell reconstitution in chronic hepatitis B and C
In chronic hepatitis B and C virus infections persistently elevated antigen levels drive CD8+
T cells toward a peculiar differentiation state known as T cell exhaustion, which poses …
T cells toward a peculiar differentiation state known as T cell exhaustion, which poses …
Elimination of hepatitis C virus has limited impact on the functional and mitochondrial impairment of HCV-specific CD8+ T cell responses
A Aregay, SO Sekyere, K Deterding, K Port, J Dietz… - Journal of …, 2019 - Elsevier
Background & Aims Hepatitis C virus (HCV)-specific CD8+ T cells are functionally impaired
in chronic hepatitis C. Even though HCV can now be rapidly and sustainably cleared from …
in chronic hepatitis C. Even though HCV can now be rapidly and sustainably cleared from …
[HTML][HTML] Deregulated intracellular pathways define novel molecular targets for HBV-specific CD8 T cell reconstitution in chronic hepatitis B
I Montali, CC Berti, M Morselli, G Acerbi, V Barili… - Journal of …, 2023 - Elsevier
Background & Aims In chronic HBV infection, elevated reactive oxygen species levels
derived from dysfunctional mitochondria can cause increased protein oxidation and DNA …
derived from dysfunctional mitochondria can cause increased protein oxidation and DNA …
[HTML][HTML] Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection
Hepatitis C virus infection (HCV) represents a unique model to characterize, from early to
late stages of infection, the T cell differentiation process leading to exhaustion of human …
late stages of infection, the T cell differentiation process leading to exhaustion of human …
[HTML][HTML] Longitudinal multi-omics analyses of the gut–liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis
RO Ali, GM Quinn, R Umarova, JA Haddad… - Nature …, 2023 - nature.com
The gut and liver are connected via the portal vein, and this relationship, which includes the
gut microbiome, is described as the gut–liver axis. Hepatitis C virus (HCV) can infect the liver …
gut microbiome, is described as the gut–liver axis. Hepatitis C virus (HCV) can infect the liver …
Eradication of HCV by direct antiviral agents restores mitochondrial function and energy homeostasis in peripheral blood mononuclear cells
Hepatitis C virus (HCV) adopts several immune evasion mechanisms such as interfering
with innate immunity or promoting T‐cell exhaustion. However, the recent direct‐antiviral …
with innate immunity or promoting T‐cell exhaustion. However, the recent direct‐antiviral …