In contrast to traditional static cold preservation of donor livers, normothermic machine
perfusion may reduce preservation injury, improve graft viability and potentially allows ex …

To reduce widespread shortages, attempts are made to use more marginal livers for
transplantation. Many of these grafts are discarded for fear of inferior survival rates or biliary …

Although normothermic machine perfusion of donor livers may allow assessment of graft
viability prior to transplantation, there are currently no data on what would be a good …

Background The persistent shortage of liver allografts contributes to significant waitlist
mortality despite efforts to increase organ donation. Normothermic machine perfusion holds …

Background. To minimize the ischemia-reperfusion injury that occurs to the liver with the
current method of preservation and transplantation, we have used an extracorporeal circuit …

Liver transplantation has become an immense success; nevertheless, far more recipients
are registered on waiting lists than there are available donor livers for transplantation. High …

BACKGROUND: Utilizing livers from donors after cardiac death could significantly expand
the donor pool. We have previously shown that normothermic (37° C) extracorporeal liver …

Donor organ shortage necessitates use of less than optimal donor allografts for
transplantation. The current cold storage preservation technique fails to preserve marginal …

Avoidance of cold ischaemic preservation damage and repair of injury sustained during
warm ischaemia and organ procurement would potentially allow many livers from extended …

Hypothermic oxygenated perfusion (HOPE) and normothermic perfusion are seen as distinct
techniques of ex situ machine perfusion of the liver. We aimed to demonstrate the feasibility …