Antioxidant supplementation of mouse embryo culture or vitrification media support more in-vivo-like gene expression post-transfer

T Truong, AJ Harvey, DK Gardner - Reproductive BioMedicine Online, 2022 - Elsevier
Research question What is the effect on mouse fetal gene expression of combined
antioxidants (acetyl-L-carnitine, N-acetyl-L-cysteine and alpha-lipoic acid; A3) when used in …

Antioxidants increase blastocyst cryosurvival and viability post-vitrification

TT Truong, DK Gardner - Human reproduction, 2020 - academic.oup.com
STUDY QUESTION What is the effect of antioxidants acetyl-L-carnitine, N-acetyl-L-cysteine
and α-lipoic acid (A3) in vitrification and warming solutions on mouse blastocyst …

Antioxidants improve mouse preimplantation embryo development and viability

TT Truong, YM Soh, DK Gardner - Human Reproduction, 2016 - academic.oup.com
STUDY QUESTION What is the effect of three antioxidants (acetyl-L-carnitine, N-acetyl-L-
cysteine and α-lipoic acid), when used individually and in combination, on mouse embryo …

Oocyte Vitrification temporarily turns on oxidation-reduction process genes in mouse preimplantation embryos

G Ruihuan, L Zhichao, G Song, F Jing, S Yijuan… - Reproductive …, 2021 - Springer
We aim to understand how oocyte vitrification impacts subsequent mouse preimplantation
embryo development at molecular level. We profiled transcriptomics of fertilized …

Antioxidant supplementation of culture medium during embryo development and/or after vitrification-warming; which is the most important?

SM Hosseini, M Forouzanfar, M Hajian, V Asgari… - Journal of Assisted …, 2009 - Springer
Purpose To determine the most optimal stage for antioxidant supplementation of culture
medium to improve developmental competence, cryotolerance and DNA-fragmentation of …

O-235 Antioxidants in culture media improve ICSI fertilisation rate: results from a randomised controlled trial

R Kelley, L Lee, F Agresta, A Huang, J Sgroi… - Human …, 2023 - academic.oup.com
Study question Does addition of three antioxidants to G-Series media during gamete
collection, insemination, and embryo culture increase the clinical pregnancy rate from fresh …

Antioxidants improve IVF outcome and subsequent embryo development in the mouse

T Truong, DK Gardner - Human Reproduction, 2017 - academic.oup.com
STUDY QUESTION What is the effect of a combination of three antioxidants (Acetyl-L-
Carnitine, N-Acetyl-L-Cysteine and α-Lipoic Acid), present in IVF medium during mouse …

Supplementing culture and vitrification-warming media with l-ascorbic acid enhances survival rates and redox status of IVP porcine blastocysts via induction of GPX1 …

M Castillo-Martín, S Bonet, R Morató, M Yeste - Cryobiology, 2014 - Elsevier
The present study sought to determine the effect of adding l-ascorbic acid (AC) to (1) in vitro
culture medium and (2) vitrification and warming solutions on redox status and …

Exogenous L-glutathione improves vitrification outcomes in murine preimplantation embryos

NS Abdul Rahman, NA Mohamed Noor Khan, Z Eshak… - Antioxidants, 2022 - mdpi.com
Vitrification is an important tool to store surplus embryos in assisted reproductive technology
(ART). However, vitrification increases oxidative damage and results in decreased viability …

Antioxidant supplementation during in vitro culture improves mitochondrial function and development of embryos from aged female mice

E Silva, AF Greene, K Strauss, JR Herrick… - Reproduction …, 2015 - CSIRO Publishing
Maternal aging results in reduced oocyte and blastocyst quality, thought to be due, in part, to
mitochondrial dysfunction and accumulation of reactive oxygen species. To reduce oxidative …