LRH-1 (liver receptor homolog-1/NR5a2) is an orphan nuclear receptor, which regulates
glucose and lipid metabolism, as well as intestinal inflammation via the transcriptional …

NLRP1 is an inflammasome forming pattern recognition receptor (PRR). When activated by
pathogen-and damage-associated molecular patterns (PAMPS/DAMPS), NLRP1 …

Nucleotide-binding domain and leucine rich repeat containing gene family receptors (NLRs)
are cytosolic proteins that respond to a variety of pathogen and host components to induce …

Proteins of the nucleotide-binding domain, leucine-rich repeat (NLR)-containing family
recently gained attention as important components of the innate immune system. Although …

The NLRP3 inflammasome is a key component of the innate immune system that induces
pro-inflammatory cytokine production and cell death. Although NLRP3 is activated by many …

NLRP1, while the first inflammasome described, has only recently begun to gain significant
attention in disease pathology, inflammation research, and potentially, as a therapeutic …

The discovery of the NLRP 3 (NLR family, pyrin domain containing 3) inflammasome
provided an important molecular mechanism in the induction of the central pro‐inflammatory …

Mammalian Nod-like receptor (NLR) proteins contribute to the regulation and induction of
innate and adaptive immunity in mammals, although the function of about half of the …

The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

A subset of Nucleotide-binding and leucine-rich repeat-containing receptors (NLRs) function
to mitigate overzealous pro-inflammatory signaling produced by NF-κB activation. Under …