Impaired neurovascular coupling has been suggested as an early pathogenic factor in
Alzheimer's disease (AD), which could serve as an early biomarker of cerebral pathology …

Alzheimer's disease (AD), the most common form of dementia, is characterized by neuronal
degeneration and cerebrovascular dysfunction. Increasing evidence indicates that …

Early impairments to neurovascular coupling have been proposed to be a key pathogenic
factor in the onset and progression of Alzheimer's disease (AD). Studies have shown …

Neurovascular coupling is a critical brain mechanism whereby changes to blood flow
accompany localised neural activity. The breakdown of neurovascular coupling is linked to …

Based on enlarged blood oxygen level-dependent (BOLD) responses in cognitively normal
subjects at risk for Alzheimer's disease (AD), compensatory neuronal hyperactivation has …

Objective: To investigate variation in the characteristics of regional cerebral blood flow
(rCBF), brain activity, and intrinsic functional connectivity (FC) across the Alzheimer's …

We compared the efficacy of neurovascular coupling and substrate supply in cerebral cortex
during severe metabolic challenges in transgenic Alzheimer's [CVN‐AD] and control …

Dysfunction in neurovascular coupling that results in a mismatch between cerebral blood
flow and neuronal activity has been suggested to play a key role in the pathogenesis of …

Background Understanding the relationship between vascular disease and Alzheimer's
disease (AD) will enhance our insight into this disease and pave the way for novel …

Combined evidence from neuroimaging and neuropathological studies shows that signs of
vascular pathology and brain hypoperfusion develop early in Alzheimer's disease (AD). To …