The development and prevalence of diseases associated with aging presents a global
health burden on society. One hallmark of aging is the loss of proteostasis which is caused …

Skeletal muscle is one of the most abundant and highly plastic tissues. The ubiquitin–
proteasome system (UPS) is recognised as a major intracellular protein degradation system …

Aging is a complex phenomenon that has detrimental effects on tissue homeostasis. The
skeletal muscle is one of the earliest tissues to be affected and to manifest age-related …

The ability to activate compensatory mechanisms in response to environmental stress is an
important factor for survival and maintenance of cellular functions. A system that is often …

Muscle atrophy complicates many diseases as well as aging, and its presence predicts both
decreased quality of life and survival. Much work has been conducted to define the …

Protein homeostasis is fundamental in normal cellular function and cell survival. The
ubiquitin–proteasome system (UPS) plays a central role in maintaining the protein …

The skeletal muscle plays an important role in maintaining whole-body mechanics,
metabolic homeostasis, and interorgan crosstalk. However, during aging, functional and …

Many systemic diseases are featured by muscle atrophy. Cellular proteins are modified by
covalent attachment to a small protein known as ubiquitin (Ub) through ubiquitination. This …

Among the four proteolytic systems in the cell, autophagy and the ubiquitin-proteasome
system (UPS) are the main proteolytic events that allow for the removal of cell debris and …

Skeletal muscles are considered the largest reservoirs of the protein pool in the body and
are critical for the maintenances of body homeostasis. Skeletal muscle atrophy is supported …