Mechanisms of MPP+-induced PC12 cell apoptosis via reactive oxygen species
Q Zhu, J Wang, Y Zhang, S Sun - … of Huazhong University of Science and …, 2012 - Springer
Apoptosis of dopaminergic neurons in the nigrostriatal projection plays a crucial role in the
pathogenesis of Parkinson's disease (PD). Although the detailed mechanisms responsible …
pathogenesis of Parkinson's disease (PD). Although the detailed mechanisms responsible …
Miltirone Attenuates Reactive Oxygen Species-Dependent Neuronal Apoptosis in MPP+-Induced Cell Model of Parkinson's Disease Through Regulating the PI3K/Akt …
H Feng, F Xi - Neurochemical Research, 2022 - Springer
Miltirone is a phenanthrene-quinone derived from Salvia miltiorrhiza Bunge with anti-
inflammatory and anti-oxidant effects. Our study aimed to explore the protective effect of …
inflammatory and anti-oxidant effects. Our study aimed to explore the protective effect of …
Role of calcium dyshomeostasis in 1-methyl-4-phenylpyridinium ion-induced apoptosis of human neuroblastoma SH-SY5Y cells
L Xu, W Li, D Lin, H Zhang, F Zou - Nan Fang yi ke da xue xue bao …, 2013 - europepmc.org
Objective To investigate the role of calcium dyshomeostasis in 1-methyl-4-phenylpyridinium
ion (MPP⁺)-induced apoptosis of human neuroblastoma SH-SY5Y cells. Methods The …
ion (MPP⁺)-induced apoptosis of human neuroblastoma SH-SY5Y cells. Methods The …
Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in …
V Anantharam, S Kaul, C Song, A Kanthasamy… - Neurotoxicology, 2007 - Elsevier
Oxidative stress is widely recognized as a key mediator of degenerative processes in
Parkinson's disease (PD). Recently, we demonstrated that the dopaminergic toxin MPP+ …
Parkinson's disease (PD). Recently, we demonstrated that the dopaminergic toxin MPP+ …
Compensatory caspase activation in MPP+-induced cell death in dopaminergic neurons
JLY Chee, XL Guan, JY Lee, B Dong, SM Leong… - Cellular and Molecular …, 2005 - Springer
Many have hypothesized that cell death in Parkinson's disease is via apoptosis and,
specifically, by the mitochondrial-mediated apoptotic pathway. We tested this hypothesis …
specifically, by the mitochondrial-mediated apoptotic pathway. We tested this hypothesis …
Proteomics analysis of MPP+-induced apoptosis in SH-SY5Y cells
H Xie, M Chang, X Hu, D Wang, M Tian, G Li… - Neurological …, 2011 - Springer
Accumulating evidence suggests that oxidative stress plays a pivotal role in dopaminergic
neurodegeneration. However, the kinds of proteins involved in the response to oxidative …
neurodegeneration. However, the kinds of proteins involved in the response to oxidative …
Melatonin attenuates 1-methyl-4-phenylpyridinium-induced PC12 cell death
J Bao, R Wu, X Zhang, Y Song, C Li - Acta Pharmacologica Sinica, 2005 - nature.com
Aim: To explore the effect of melatonin on PC12 cell death induced by 1-methyl-4-
phenylpyridinium (MPP+). Methods: MTT assay, lactate dehydrogenase (LDH) efflux assay …
phenylpyridinium (MPP+). Methods: MTT assay, lactate dehydrogenase (LDH) efflux assay …
Implication of the c-Jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC …
G Wang, L Zhou, Y Zhang, M Dong, X Li, J Liu… - Neuroscience Letters, 2011 - Elsevier
Apoptosis is a widely accepted component of the pathogenesis of Parkinson's disease (PD),
a debilitating neurodegenerative disorder characterized by loss of dopaminergic neurons in …
a debilitating neurodegenerative disorder characterized by loss of dopaminergic neurons in …
Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells
J Wang, HM Duhart, Z Xu, TA Patterson… - Neurochemistry …, 2008 - Elsevier
Parkinson's disease (PD) is a common neurodegenerative disease characterized by
progressive loss of midbrain dopaminergic neurons with unknown etiology. MPP+ (1-methyl …
progressive loss of midbrain dopaminergic neurons with unknown etiology. MPP+ (1-methyl …
NF-κB mediates MPP+-induced apoptotic cell death in neuroblastoma cells SH-EP1 through JNK and c-Jun/AP-1
HJ Yang, L Wang, YY Xia, PN Chang… - Neurochemistry …, 2010 - Elsevier
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons in
substantia nigra with unknown etiology. Neuropathology seen in the brains of PD patients …
substantia nigra with unknown etiology. Neuropathology seen in the brains of PD patients …