The mechanisms that regulate angiogenesis in hypoxia or hypoxic microenvironment are
modulated by several pro-and antiangiogenic factors. Hypoxia-inducible factors (HIFs) have …

Maintenance of oxygen homeostasis is critical for the survival of multicellular organs. As a
result, both invertebrates and vertebrates have developed highly specialized mechanisms to …

Hypoxia-inducible factors (HIFs) regulate the transcription of genes that mediate the
response to hypoxia. HIFs are constantly expressed and degraded under normoxia, but …

Angiogenesis is mostly an adaptive response to tissue hypoxia, which occurs under a wide
variety of situations ranging from embryonic development to tumor growth. In general …

Abstract Hypoxia-Inducible Factor (HIF)-1 is a dimeric protein complex that plays an integral
role in the body's response to low oxygen concentrations, or hypoxia. HIF-1 is among the …

Angiogenesis is a key enabling feature of mammalian embryonic development and tumor
progression, which provides oxygen and nutrients that are required for vessel growth and …

The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …

The hypoxia-inducible factor (HIF) is a transcription factor that plays a key role in the
response of cells to oxygen levels. HIF is a heterodimer of α-and βsubunits where the a …

The vascular network delivers oxygen (O2) and nutrients to all cells within the body. It is
therefore not surprising that O2 availability serves as a primary regulator of this complex …

Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in
ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified …