Technologies that induce antigen-specific immune tolerance by mimicking naturally
occurring mechanisms have the potential to revolutionize the treatment of many immune …

The prevalence of immune-mediated disorders, including autoimmune conditions and
allergies, is steadily increasing. However, current therapeutic approaches are often non …

During autoimmunity or organ transplant rejection, the immune system attacks host or
transplanted tissue, causing debilitating inflammation for millions of patients. There is no …

Autoimmunity and allergies affect a large number of people across the globe. Current
approaches to these diseases target cell types and pathways that drive disease, but these …

Highlights•B cell tolerance can occur by clustering the B cell receptor with certain B cell-
surface receptors.•T cell tolerance can occur by antigen presentation from dendritic cells …

Regenerative therapies that use allogeneic cells are likely to encounter immunological
barriers similar to those that occur with transplantation of solid organs and allogeneic …

Autoimmune diseases occur when cells of the adaptive immune system incorrectly
recognize and attack “self” tissues. Importantly, the proliferation and differentiation of these …

Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …

Strategies for inducing immune tolerance are fundamentally similar across a spectrum of
immune‐mediated disorders, including allergic disease, autoimmunity, and rejection of …

Conventional therapies for immune-mediated diseases, including autoimmune disorders,
transplant reactions, and allergies, have undergone a radical evolution in the last few …