Virus infections have been linked to the induction of autoimmunity and disease development
in human type 1 diabetes. Experimental models have been instrumental in deciphering …

Viruses can cause but can also prevent autoimmune disease. This dualism has certainly
hampered attempts to establish a causal relationship between viral infections and type 1 …

We developed two distinct transgenic mouse models in which virus induced insulin-
dependent(type 1) diabetes mellitus (IDDM). In one of these lines, the unique viral transgene …

The portrait of autoimmune diabetes mellitus or type I diabetes can be copied by a
transgenic model in which either the nucleoprotein (NP) or glycoprotein (GP) of lymphocytic …

We investigated the potential association between viruses and insulin-dependent(type 1)
diabetes (IDDM) by developing a transgenic mouse model. By inserting into these mice a …

Insulin‐dependent diabetes mellitus (IDDM) is an autoimmune disease whose etiology is
complex. Both genetic susceptibility, which is polygenic, and environmental factors …

Background Rat models of diabetes have emerged as a powerful experimental tool for
addressing the role of microbial pathogens in the mechanism of autoimmune diabetes. We …

Juvenile onset insulin-dependent diabetes mellitus (IDDM) is a serious health problem that
affects several million people each year [l-31. In IDDM, pancreatic/?-cells are destroyed by a …

The braking of tolerance or unresponsiveness to self-antigens, involving the activation of
autoreactive lymphocytes, is a critical event leading to autoimmune diseases. The precise …

Type 1 diabetes (T1D) is an autoimmune disease that is caused by the destruction of insulin-
producing β cells. Viral infections induce immune responses that can damage β cells and …