Micronucleus (MN) induction is an established cytogenetic end point for evaluating structural
and numerical chromosomal alterations in genotoxicity testing. A semi-automated scoring …

The toxicological relevance of the micronucleus (MN) test is well defined: it is a multi-target
genotoxic endpoint, assessing not only clastogenic and aneugenic events but also some …

An automated approach for scoring in vitro micronuclei (MN) has been described in which
flow cytometric analysis is combined with compound exposure, processing, and sampling in …

Automated image analysis scoring of micronuclei (MN) in cells can facilitate the objective
and rapid measurement of genetic damage in mammalian and human cells. This approach …

The Organization for Economic Co-operation and Development (OECD) has recently
adopted Test Guideline 487 (TG487) for conducting the in vitro micronucleus (MNvit) assay …

The in vitro micronucleus test (MNT) is a well-established test for early screening of new
chemical entities in industrial toxicology. For assessing the clastogenic or aneugenic …

Micronuclei (MN) frequencies in peripheral blood lymphocytes have been used worldwide
as a biomarker of chromosomal damage for genotoxicity testing and biomonitoring studies …

The use of manual microscopy for the scoring of chromosome damage in the in vitro
micronucleus assay is often associated with user subjectivity. This level of subjectivity can …

The relative simplicity of the in vitro micronucleus (MNvit) endpoint has made it amenable to
several automated scoring approaches. Flow cytometry is one such scoring platform that has …

The in vitro micronucleus (MN) assay is often used to evaluate cytotoxicity and genotoxicity
but scoring the assay via manual microscopy is laborious and introduces uncertainty in …