GWAS studies have identified hundreds of loci that associate with obesity and type 2
diabetes. However, the functional relevance of the genetic variants, and their impact on …

Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are
caused by an interchange between environmental and genetic factors. Recently, a number …

Genome-wide association studies (GWAS) of obesity-related traits are defining the genetic
architecture of obesity, revealing genes and mechanisms for disease. GWAS have been …

Obesity increases the risk of developing comorbidities such as cardiovascular and metabolic
diseases. However, not all obese individuals develop comorbidities, and those that do not …

Within the last 3 years, genome-wide association studies (GWAS) have had unprecedented
success in identifying loci that are involved in common diseases. For example, more than 35 …

Genome-wide association studies (GWAS) have identified many disease-associated
variants, yet mechanisms underlying these associations remain unclear. To understand …

The prevalence of obesity and diabetes, which are heritable traits that arise from the
interactions of multiple genes and lifestyle factors, continues to rise worldwide, causing …

While genome-wide association studies (GWAS) have identified variants and genes
associated with human disease, a comprehensive understanding of the genetic architecture …

Genome-wide association studies (GWAS) have accelerated the discovery of genetic
variants associated with susceptibility to common complex diseases, such as obesity …

Aims/hypothesis While genome-wide association studies (GWASs) have been successful in
identifying novel variants associated with various diseases, it has been much more difficult …