[图书][B] Targeting the Toxin B glucosyltransferase domain of NAP1/B1/027 Clostridioides difficile using an attenuated Salmonella enterica Typhimurium vaccine vector
P Upadhyaya - 2022 - search.proquest.com
Clostridioides difficile (C. difficile) is the most common cause of nosocomial antibiotic-
associated diarrhea in developed countries and is classified as an urgent threat by the …
associated diarrhea in developed countries and is classified as an urgent threat by the …
[图书][B] Preclinical development of a novel vaccine targeting Clostridioides difficile using an attenuated Salmonella Typhimurium vector
K Winter - 2022 - search.proquest.com
Clostridioides difficile infection (CDI) is one of the most important nosocomial infections in
the world. In 2012, approximately 40,000 CDI cases were reported in Canada with a cost of …
the world. In 2012, approximately 40,000 CDI cases were reported in Canada with a cost of …
Novel Chimeric Protein Vaccines Against Clostridium difficile Infection
Clostridium difficile infection (CDI) is the leading cause of world-wide nosocomial acquired
diarrhea in adults. Active vaccination is generally accepted as a logical and cost-effective …
diarrhea in adults. Active vaccination is generally accepted as a logical and cost-effective …
[HTML][HTML] Clostridium difficile chimeric toxin receptor binding domain vaccine induced protection against different strains in active and passive challenge models
JH Tian, G Glenn, D Flyer, B Zhou, Y Liu, E Sullivan… - Vaccine, 2017 - Elsevier
Clostridium difficile is the number one cause of nosocomial antibiotic-associated diarrhea in
developed countries. Historically, pathogenesis was attributed two homologous …
developed countries. Historically, pathogenesis was attributed two homologous …
Vaccination against Clostridium difficile by Use of an Attenuated Salmonella enterica Serovar Typhimurium Vector (YS1646) Protects Mice from Lethal Challenge
K Winter, L Xing, A Kassardjian, BJ Ward - Infection and immunity, 2019 - Am Soc Microbiol
Clostridium difficile disease is mediated primarily by toxins A and B (TcdA and TcdB,
respectively). The receptor binding domains (RBD) of TcdA and TcdB are immunogenic, and …
respectively). The receptor binding domains (RBD) of TcdA and TcdB are immunogenic, and …
An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivo
SM Baliban, A Michael, B Shammassian… - Infection and …, 2014 - Am Soc Microbiol
Clostridium difficile-associated disease (CDAD) constitutes a large majority of nosocomial
diarrhea cases in industrialized nations and is mediated by the effects of two secreted toxins …
diarrhea cases in industrialized nations and is mediated by the effects of two secreted toxins …
Multimodal vaccination targeting the receptor binding domains of Clostridioides difficile toxins A and B with an attenuated Salmonella Typhimurium vector (YS1646) …
K Winter, S Houle, CM Dozois, BJ Ward - Microbiology Spectrum, 2024 - Am Soc Microbiol
Developing a vaccine against Clostridioides difficile is a key strategy to protect the elderly.
Two candidate vaccines using a traditional approach of intramuscular (IM) delivery of …
Two candidate vaccines using a traditional approach of intramuscular (IM) delivery of …
Development of an Effective Nontoxigenic Clostridioides difficile–Based Oral Vaccine against C. difficile Infection
The symptoms of Clostridioides difficile infection (CDI) are largely attributed to two C. difficile
toxins, TcdA and TcdB. Significant efforts have been devoted to developing vaccines …
toxins, TcdA and TcdB. Significant efforts have been devoted to developing vaccines …
Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains
S Secore, S Wang, J Doughtry, J Xie, M Miezeiewski… - PLoS …, 2017 - journals.plos.org
Clostridium difficile infections (CDI) are a leading cause of nosocomial diarrhea in the
developed world. The main virulence factors of the bacterium are the large clostridial toxins …
developed world. The main virulence factors of the bacterium are the large clostridial toxins …
683. Understanding Clostridioides difficile toxinB gene conservation through surveillance of public data
K Mulholland, V Godfrey, AM Stanley… - Open Forum …, 2023 - academic.oup.com
Background Clostridioides difficile infection (CDI) is the leading cause of antibiotic and
healthcare-associated infective diarrhea. It is linked to 365,000 infections and causes …
healthcare-associated infective diarrhea. It is linked to 365,000 infections and causes …