Probing the cis interactions of the inhibitory receptor Siglec-7 with α2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific …
Abstract Siglec-7 is a CD33-related sialic acid-binding Ig-like lectin expressed strongly on
NK cells, where it can function as an inhibitory receptor. Its sialic acid-binding activity on NK …
NK cells, where it can function as an inhibitory receptor. Its sialic acid-binding activity on NK …
A small region of the natural killer cell receptor, Siglec-7, is responsible for its preferred binding to α2, 8-disialyl and branched α2, 6-sialyl residues: a comparison with …
T Yamaji, T Teranishi, MS Alphey, PR Crocker… - Journal of Biological …, 2002 - ASBMB
Siglec-7 is a sialic acid-binding lectin recently identified as an inhibitory receptor on natural
killer cells. Here we characterize the sugar-binding specificity of Siglec-7 expressed on …
killer cells. Here we characterize the sugar-binding specificity of Siglec-7 expressed on …
Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec‐7‐dependent and‐independent mechanisms
G Nicoll, T Avril, K Lock, K Furukawa… - European journal of …, 2003 - Wiley Online Library
Siglec‐7 is a sialic acid binding receptor with inhibitory potential, expressed on human NK
cells and monocytes. It has an unusual binding preference for α2, 8‐linked disialic acids …
cells and monocytes. It has an unusual binding preference for α2, 8‐linked disialic acids …
Siglec-7 undergoes a major conformational change when complexed with the α (2, 8)-disialylganglioside GT1b
The siglecs are a group of mammalian sialic acid binding receptors expressed
predominantly in the immune system. The CD33-related siglecs show complex recognition …
predominantly in the immune system. The CD33-related siglecs show complex recognition …
Discovery of a new sialic acid binding region that regulates Siglec-7
N Yamakawa, Y Yasuda, A Yoshimura, A Goshima… - Scientific reports, 2020 - nature.com
Siglec-7 is a human CD33-like siglec, and is localised predominantly on human natural
killer (NK) cells and monocytes. Siglec-7 is considered to function as an immunoreceptor in …
killer (NK) cells and monocytes. Siglec-7 is considered to function as an immunoreceptor in …
Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor
Here we characterize Siglec-10 as a new member of the Siglec family of sialic acid-binding
Ig-like lectins. A full-length cDNA was isolated from a human spleen library and the …
Ig-like lectins. A full-length cDNA was isolated from a human spleen library and the …
Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells
A Yoshimura, Y Asahina, LY Chang, T Angata… - Journal of Biological …, 2021 - ASBMB
Sialic acid (Sia)-binding immunoglobulin-like lectin 7 (Siglec-7) is an inhibitory receptor
primarily expressed on natural killer (NK) cells and monocytes. Siglec-7 is known to …
primarily expressed on natural killer (NK) cells and monocytes. Siglec-7 is known to …
The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design
H Attrill, H Takazawa, S Witt, S Kelm… - Biochemical …, 2006 - portlandpress.com
Siglecs (sialic acid binding Ig-like lectins) are transmembrane receptors for sialylated
glycoconjugates that modulate cellular interactions and signalling events in the …
glycoconjugates that modulate cellular interactions and signalling events in the …
The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and-9, CD33-related Siglecs …
Abstract Siglec-7 and Siglec-9 are two members of the recently characterized CD33-related
Siglec family of sialic acid binding proteins and are both expressed on human monocytes …
Siglec family of sialic acid binding proteins and are both expressed on human monocytes …
Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes
G Nicoll, J Ni, D Liu, P Klenerman, J Munday… - Journal of Biological …, 1999 - ASBMB
We describe the characterization of sialic acid-binding Ig-like lectin-7 (siglec-7), a novel
member of the siglec subgroup of the immunoglobulin superfamily. A full-length cDNA …
member of the siglec subgroup of the immunoglobulin superfamily. A full-length cDNA …