Ischemic stroke is one of the most devastating complications of sickle cell anemia (SCA).
Previous studies have shown that intracardiac shunting including patent foramen ovale …

Although individuals with sickle cell disease (SCD) are at increased risk for stroke, the
underlying pathophysiology is incompletely understood. Intracardiac shunting via a patent …

OBJECTIVE: To determine the prevalence of potential intracardiac shunts, including patent
foramen ovale (PFO), in children with sickle cell disease (SCD) and stroke. STUDY DESIGN …

Sickle cell disease (SCD) is an inherited monogenic hemoglobinopathy characterized by
formation of sickle erythrocytes under conditions of deoxygenation. Sickle erythrocytes can …

The support has been provided by clinical trials and guidelines for managing patent foramen
ovale (PFO) in adults; however, the optimal approach is still unclear for treating PFO in …

Background Patent foramen ovale (PFO) closure in patients with stroke has been
controversial. Recent evidence points towards the benefit of closure compared to medical …

Background and Objectives To determine the significance of patent foramen ovale (PFO) in
childhood stroke, we compared PFO prevalence, PFO features, and stroke recurrence risk in …

Background: Numerous studies in adults have reported a robust association between patent
foramen ovale (PFO) and cryptogenic arterial ischemic stroke (AIS), particularly in younger …

Summary 'Paradoxical'embolization via intracardiac or intrapulmonary right‐to‐left shunts
(RLS) is an established cause of stroke. Hypercoagulable states and increased right heart …

Background Sickle cell anemia (SCA) is the leading cause of childhood stroke. We aimed to
evaluate whether altered cerebral flow velocities, as measured by transcranial Doppler …