Time course of cerebrospinal fluid inflammatory biomarkers and relationship to 6-month neurologic outcome in adult severe traumatic brain injury

EL Nwachuku, AM Puccio, A Adeboye… - Clinical neurology and …, 2016 - Elsevier
Objective Activation of the inflammatory cascade is a known pathophysiologic process in
severe traumatic brain injury (TBI) with yet non-standardized scientific data regarding …

[HTML][HTML] Blood-based biomarkers of inflammation in mild traumatic brain injury: A systematic review

K Visser, M Koggel, J Blaauw, HJ van der Horn… - Neuroscience & …, 2022 - Elsevier
Abstract VISSER, K., M. Koggel, J. Blaauw, HJvd Horn, B. Jacobs, and Jvd Naalt. Blood
based biomarkers of inflammation in mild traumatic brain injury: A systematic review …

Severe traumatic brain injury (TBI) modulates the kinetic profile of the inflammatory response of markers for neuronal damage

CR Schindler, T Lustenberger, M Woschek… - Journal of clinical …, 2020 - mdpi.com
The inflammatory response plays an important role in the pathophysiology of multiple
injuries. This study examines the effects of severe trauma and inflammatory response on …

Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury

P Lassarén, C Lindblad, A Frostell… - Journal of …, 2021 - Springer
Background Neuroinflammation following traumatic brain injury (TBI) has been shown to be
associated with secondary injury development; however, how systemic inflammatory …

Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury

A Singhal, AJ Baker, GMT Hare, FX Reinders… - Journal of …, 2002 - liebertpub.com
Acute inflammation plays a significant role in the pathophysiology of traumatic brain injury
(TBI). However, the specific relationships between inflammatory mediators and patient …

Principal components derived from CSF inflammatory profiles predict outcome in survivors after severe traumatic brain injury

RG Kumar, JE Rubin, RP Berger, PM Kochanek… - Brain, behavior, and …, 2016 - Elsevier
Studies have characterized absolute levels of multiple inflammatory markers as significant
risk factors for poor outcomes after traumatic brain injury (TBI). However, inflammatory …

Acute CSF interleukin-6 trajectories after TBI: associations with neuroinflammation, polytrauma, and outcome

RG Kumar, ML Diamond, JA Boles, RP Berger… - Brain, behavior, and …, 2015 - Elsevier
Traumatic brain injury (TBI) results in a significant inflammatory burden that perpetuates the
production of inflammatory mediators and biomarkers. Interleukin-6 (IL-6) is a pro …

Pro-and anti-inflammatory biomarkers and traumatic brain injury outcomes: a review

T Rodney, N Osier, J Gill - Cytokine, 2018 - Elsevier
Abstract Traumatic Brain Injury (TBI) triggers a cascade of secondary biological and
physiological effects that are variable, depending on the severity, location, and complexity of …

High-sensitivity C-reactive protein is a prognostic biomarker of six-month disability after traumatic brain injury: results from the TRACK-TBI study

LB Xu, JK Yue, F Korley, AM Puccio, EL Yuh… - Journal of …, 2021 - liebertpub.com
Systemic inflammation impacts outcome after traumatic brain injury (TBI), but most TBI
biomarker studies have focused on brain-specific proteins. C-reactive protein (CRP) is a …

Neuroinflammatory biomarkers for traumatic brain injury diagnosis and prognosis: A TRACK-TBI pilot study

JK Yue, FH Kobeissy, S Jain, X Sun… - Neurotrauma …, 2023 - liebertpub.com
The relationship between systemic inflammation and secondary injury in traumatic brain
injury (TBI) is complex. We investigated associations between inflammatory markers and …