Overexpression of the multi-drug transporter P-glycoprotein, encoded by the ABCB1 gene, is
a clinically relevant problem in acute myeloid leukemia (AML). Polymorphisms in ABCB1 …

Drug resistance is a clinically relevant problem in the treatment of acute myeloid leukaemia
(AML). We have previously reported a relationship between single nucleotide …

Purpose To investigate the influence of ABCB1 polymorphisms on prognostic outcomes in
Chinese patients with de novo intermediate-risk acute myeloid leukemia (AML) and to …

Inherited differences in xenobiotic transport and metabolism may play an important role in
the development of adult acute myeloid leukemia (AML) and response to the chemotherapy …

The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences the
pharmacokinetics of anti-cancer drugs. We hypothesized that variants of ABCB1 affect …

The ABCB1 gene encodes for P-glycoprotein (P-gp), an efflux pump for a variety of
xenobiotics. The role of ABCB1 polymorphisms in acute myeloid leukemia (AML) outcomes …

Objectives The classical multidrug resistance (MDR) gene MDR1 (ABCB1) encodes for the
drug efflux pump P‐glycoprotein (P‐gp). P‐gp expression is an adverse prognostic factor for …

Despite improvements in treatment of different types of leukemia, not all patients respond
optimally for a particular treatment. Some treatments will work better for some, while being …

Acute myeloid leukemia (AML) is one of the most common hematological neoplasia causing
death worldwide. The long-term overall survival is unsatisfactory due to many factors …

The aim of this study is to investigate the association of ABCB1 polymorphisms with
susceptibility to adult acute leukemia, and the influence of ABCB1 polymorphisms on the …