Insulin promotes glucose uptake by triggering the translocation of glucose transporter type 4
(GLUT4) from intracellular vesicles to the plasma membrane through exocytosis. GLUT4 …

The exocyst is an octameric molecular complex that drives vesicle trafficking in adipocytes, a
rate-limiting step in insulin-dependent glucose uptake. This study assessed the role of the …

Skeletal muscle handles~ 80–90% of the insulin-induced glucose uptake. In skeletal
muscle, insulin binding to its cell surface receptor triggers redistribution of intracellular …

Insulin regulates cellular glucose uptake by changing the amount of glucose transporter-4
(GLUT4) in the plasma membrane through stimulation of GLUT4 exocytosis. However, how …

Skeletal muscle is responsible for the majority of glucose disposal following meals, and this
is achieved by insulin-mediated trafficking of glucose transporter type 4 (GLUT4) to the cell …

Insulin stimulates glucose transport in adipocytes and muscle by inducing the redistribution
of Glut4 from intracellular locations to the plasma membrane. The fusion of Glut4-containing …

Lipid raft microdomains act as organizing centers for signal transduction. We report here that
the exocyst complex, consisting of Exo70, Sec6, and Sec8, regulates the …

The exocyst is an octameric complex involved in docking or tethering of secretory vesicles to
fusion sites of the plasma membrane. Sec6 is the core subunit of the exocyst complex. Here …

Exocytosis is a vesicle fusion process driven by soluble N‐ethylmaleimide‐sensitive factor
attachment protein receptors (SNAREs). A classic exocytic pathway is insulin‐stimulated …

The signal transduction pathway leading from the insulin receptor to stimulate the fusion of
vesicles containing the glucose transporter GLUT4 with the plasma membrane in adipocytes …