Background The accumulation of mutagenic substances in the human body may result in
DNA metabolism disruption followed by carcinogenesis. As a consequence of mutations in …

Many intensive studies are devoted to identifying novel cancer diagnostics or therapy
strategies that would boost cancer therapy efficacy and recovery rates. Importantly …

The possible interaction between gene polymorphisms and risk of cancer progression is
very interesting. Polymorphisms in multi-drug resistance genes have an important role in …

The ABCB1 gene encodes a permeability glycoprotein, which is one of the most extensively
studied human adenosine-triphosphate (ATP)-dependent efflux transporters. Permeability …

Purpose Genetic variants of ABCB1 gene contributed to cancer susceptibility and
interindividual differences in chemotherapy response. Therefore, we investigated the …

The ABCB1 gene encodes the P-glycoprotein, an efflux pump for some antineoplastic
agents which acts as a resistance mechanism to chemotherapy. Three SNPs (C3435T …

Background Transportation of anticancer drugs such as anthracyclines across the
membrane is regulated by P-glycoprotein encoded by the human multidrug resistance gene …

Previous epidemiological studies have evaluated the association between the ABCB1
polymorphism and the risk of breast cancer with conflicting results. Hence, we conducted a …

Background Breast cancer is the most common cause of cancer death among women.
Several studies have investigated the relationship between the C3435T polymorphism of …

Purpose To investigate the association of ABCB1-C3435T transition with breast cancer risk
which was followed by a meta-analysis. Methods In a case-control study we collected blood …