Telomere repeats protect linear chromosomes from degradation, and telomerase has a
prominent role in their maintenance. Telomerase has telomere-independent effects on cell …

Differential regulation of telomerase reverse transcriptase (TERT) contributes to the distinct
aging and tumorigenic processes in humans and mice. Here, we report that the hTERT gene …

Recent evidence points to extra-telomeric, noncanonical roles for telomerase in regulating
stem cell function. In this study, human embryonic stem cells (hESCs) were cultured in 20 …

Telomerase elongates telomeres and is crucial for maintaining genomic stability. While stem
cells and cancer cells display high telomerase activity, normal somatic cells lack telomerase …

Differential regulation of telomerase reverse transcriptase (TERT) genes contribute to
distinct aging and tumorigenic processes in humans and mice. To study TERT regulation …

Embryonic stem cells (ESC) are a unique cell population with the ability to self-renew and
differentiate into all three germ layers. Human ESC express the telomerase reverse …

Telomeres are regions of repeated DNA sequence that cap the ends of eukaryotic
chromosomes. They act as disposable safeguards to prevent the loss of important genetic …

Telomerase is tightly regulated in humans relative to mice, owing to the differential
regulation of TERT genes. To explore hTERT regulation in vivo, we engineered mice with a …

Telomerase serves a critical role in stem cell function and tissue homeostasis. This role
depends on its ability to synthesize telomere repeats in a manner dependent on the reverse …

Telomeres undergo shortening with each cell division, serving as biomarkers of human
aging, which is characterized by short telomeres and restricted telomerase expression in …