Vaccines that target Plasmodium falciparum gametocytes have the potential to reduce
malaria transmission and are thus attractive targets for malaria control. However, very little is …

Introduction Naturally acquired immune responses against antigens expressed on the
surface of mature gametocytes develop in individuals living in malaria-endemic areas …

Individuals infected with P. falciparum develop antibody responses to intra-erythrocytic
gametocyte proteins and exported gametocyte proteins present on the surface of infected …

Why there are so few gametocytes (the transmission stage of malaria) in the blood of
humans infected with Plasmodium spp. is intriguing. This may be due either to reproductive …

Background The asexual blood stages of the human malaria parasite Plasmodium
falciparum produce highly immunogenic polymorphic antigens that are expressed on the …

Malaria elimination efforts would benefit from vaccines that block transmission of
Plasmodium falciparum gametocytes from humans to mosquitoes. A clear understanding of …

Understanding the targets and mechanisms of human immunity to malaria caused by
Plasmodium falciparum is crucial for advancing effective vaccines and developing tools for …

Background Antigametocyte-specific immune responses may regulate Plasmodium
falciparum gametocyte density, providing the rationale for pursuing transmission-blocking …

Subclinical infections that serve as reservoir populations to drive transmission remain a
hurdle to malaria control. Data on infection dynamics in a geographical area is required to …

Background Naturally acquired immune responses against sexual stages of P. falciparum
can reduce the transmission of malaria from humans to mosquitoes. These antigens are …