Is clopidogrel the antiplatelet drug of choice for high‐risk patients with stroke/TIA?: yes

HC DIENER - Journal of Thrombosis and Haemostasis, 2005 - jthjournal.org
Recurrence risk after transient ischemic attack (TIA) or ischemic stroke (IS) ranges from 5 to
20% per year [1–3]. The risk is highest immediately after the first event [4–6]. Numerous trials …

Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients: a prespecified substudy of the Clopidogrel for High …

GJ Hankey, W Hacke, JD Easton, SC Johnston, JL Mas… - stroke, 2010 - Am Heart Assoc
Background and Purpose—Disabling stroke is costly and considered by some patients a
fate worse than death. We aimed to determine whether clopidogrel reduces the rate and …

Combination aspirin and clopidogrel for secondary prevention of ischemic stroke

TS Field, M Nakajima, OR Benavente - Current treatment options in …, 2013 - Springer
Opinion statement Though antiplatelet agents are the mainstay of antithrombotic therapy for
secondary prevention of noncardioembolic cerebral ischemic events, the efficacy of …

Evaluation of antiplatelet agents for secondary prevention of stroke using mixed treatment comparison meta-analysis

RJ Malloy, AO Kanaan, MA Silva, JL Donovan - Clinical therapeutics, 2013 - Elsevier
Background The current guidelines recommend various antiplatelet agents used alone or in
combination for secondary prevention of noncardioembolic stroke. Objective The purpose of …

Abstract T P334: Clopidogrel and Aspirin versus Aspirin Alone for Prevention of Recurrent Ischemic Lesion in Acute Atherothrombotic Stroke: A Randomized, Double …

SH Lee, HY Kim, HJ Bae, KH Yu, GM Kim, DE Kim… - Stroke, 2014 - Am Heart Assoc
Background: Combination treatment with clopidogrel and aspirin is not currently
recommended for secondary prevention of stroke, but its superior effect to aspirin alone has …

Safety of clopidogrel and aspirin for stroke prevention: implications of the CHARISMA trial

S Ruland - Drug safety, 2008 - Springer
Antiplatelet therapy is universally recommended for the prevention of recurrent events in
patients with noncardioembolic ischaemic stroke or transient ischaemic attack (TIA), acute …

Secondary prevention of stroke and the expanding role of the neurologist

MJ Alberts - Cerebrovascular Diseases, 2002 - karger.com
Stroke is the leading cause of adult disability and dependency in western society. Following
stroke, the risk of myocardial infarction (MI) is increased by a factor of around 2–3 compared …

The MATCH study results in the context of secondary stroke prevention

M Fisher, A Davalos - Stroke, 2004 - Am Heart Assoc
The performance of randomized clinical trials provides evidence-based medical information
to clinicians and impacts on day-to-day treatment decisions. Many secondary stroke …

Comparative efficacy and safety of multiple antiplatelet therapies for secondary prevention of ischemic stroke or transient ischemic attack: A network meta-analysis

R Xiang, R Han, J Yang, M Zhao, Q Zhao… - Journal of the …, 2019 - Elsevier
Background Antiplatelet therapies for secondary prevention of ischemic stroke or transient
ischemic attack (TIA) is a highly active research topic with five critical drugs obtained by …

Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events

PA Ringleb, DL Bhatt, AT Hirsch, EJ Topol, W Hacke - Stroke, 2004 - Am Heart Assoc
Background and Purpose—The goal of this study was to examine the influence of
preexisting symptomatic atherosclerotic disease on subsequent ischemic event rates and …