Statins are inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in
cholesterol biosynthesis, that are highly effective in reducing plasma low-density lipoprotein …

Aim: We evaluated the evidence of pharmacogenetic associations with statins in a
systematic review. Methods: Two separate outcomes were considered of interest …

Interindividual variability in response to 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase
inhibitors, or statins, with regard to both efficacy and safety is an obvious target for …

Statins, also known as HMG-CoA reductase inhibitors, are one of the most potently
prescribed and thoroughly researched medications, predominantly utilized for managing …

Pharmacogenomics of statin therapy: any new insights in effi... : Current Opinion in
Lipidology Pharmacogenomics of statin therapy: any new insights in efficacy or safety …

Statins are a cornerstone of the pharmacologic treatment and prevention of atherosclerotic
cardiovascular disease. Atherosclerotic disease is a predominant cause of mortality and …

Statins are the most widely used group of lipid-lowering drugs and they have been shown to
be effective in the prevention of cardiovascular disease, primarily by reducing plasma low …

Cardiovascular disease has become the global leading cause of death worldwide,
representing the most frequent cause of morbidity and mortality in the developed world …

Statins are the most commonly prescribed class of drug worldwide and therapy is highly
effective in reducing low-density lipoprotein cholesterol levels and cardiovascular events …

Background: Inter-individual variation in response to statins (efficacy and toxicity) has been
described and may be due to polymorphisms implicated in drug pharmacokinetics or …