Statins effectively lower LDL cholesterol levels in large studies and the observed
interindividual response variability may be partially explained by genetic variation. Here we …

Indicated for treating hyperlipidemias and for the prevention of cardiovascular disease
(CVD), statins rank among the most commonly prescribed drug classes. While statins are …

Pharmacogenetics investigates heritable genetic polymorphisms that can effect responses
to drug therapy. The main application of pharmacogenetics is genotype-guided dosing of …

Atorvastatin, prescribed for the treatment of hypercholesterolemia, demonstrated
overwhelming benefits in reducing cardiovascular morbidity and mortality. However, many …

Statins are widely prescribed and are established as first-line therapy for the primary and
secondary prevention of coronary artery disease. However, the benefit of treatment varies …

Background: In the era of precision medicine, more attention is paid to the search for
predictive markers of treatment efficacy and tolerability. Statins are one of the classes of …

What is known and objective Statins are widely used worldwide in the prevention and
treatment of coronary atherosclerotic heart disease and ischaemic stroke. However, in …

Statins are the most commonly used drugs in patients with dyslipidemia. Among the patients,
a significant inter-individual variability with supposed strong genetic background in statin …

We investigated genetic determinants of single‐dose simvastatin pharmacokinetics in a
prospective study of 170 subjects and a retrospective cohort of 59 healthy volunteers. In a …

Aims Statins reduce LDL cholesterol (LDL-C) and the risk of vascular events, but it remains
uncertain whether there is clinically relevant genetic variation in their efficacy. This study of …