Pharmacogenetics and statin treatment: reality or theory?
E Bousoula, V Kolovou, D Perrea… - Current vascular …, 2015 - ingentaconnect.com
Pharmacogenetics investigates heritable genetic polymorphisms that can effect responses
to drug therapy. The main application of pharmacogenetics is genotype-guided dosing of …
to drug therapy. The main application of pharmacogenetics is genotype-guided dosing of …
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
I Postmus, S Trompet, HA Deshmukh… - Nature …, 2014 - nature.com
Statins effectively lower LDL cholesterol levels in large studies and the observed
interindividual response variability may be partially explained by genetic variation. Here we …
interindividual response variability may be partially explained by genetic variation. Here we …
[HTML][HTML] Statin pharmacogenomics: pursuing biomarkers for predicting clinical outcomes
JP Kitzmiller, PF Binkley, SR Pandey, AM Suhy… - Discovery …, 2013 - ncbi.nlm.nih.gov
Indicated for treating hyperlipidemias and for the prevention of cardiovascular disease
(CVD), statins rank among the most commonly prescribed drug classes. While statins are …
(CVD), statins rank among the most commonly prescribed drug classes. While statins are …
Genetic contribution to lipid target achievement with statin therapy: a prospective study
C Ruiz-Iruela, B Candas-Estebanez… - The …, 2020 - nature.com
Statin therapy response is highly variable. Variants of lipid metabolism genes and statin
pharmacokinetic modulators could play a role, however, the impact of most of these variants …
pharmacokinetic modulators could play a role, however, the impact of most of these variants …
SLCO1B1 phenotype and CYP3A5 polymorphism significantly affect atorvastatin bioavailability
P Zubiaur, MD Benedicto, G Villapalos-García… - Journal of Personalized …, 2021 - mdpi.com
Atorvastatin, prescribed for the treatment of hypercholesterolemia, demonstrated
overwhelming benefits in reducing cardiovascular morbidity and mortality. However, many …
overwhelming benefits in reducing cardiovascular morbidity and mortality. However, many …
Pharmacogenomics of statin responsiveness
K Kajinami, H Akao, E Polisecki, EJ Schaefer - The American journal of …, 2005 - Elsevier
Statins are widely prescribed and are established as first-line therapy for the primary and
secondary prevention of coronary artery disease. However, the benefit of treatment varies …
secondary prevention of coronary artery disease. However, the benefit of treatment varies …
[PDF][PDF] Impact of variants within seven candidate genes on statin treatment efficacy
M Vrablík, JA Hubácek, D Dlouhá, V Lánská… - Physiological …, 2012 - biomed.cas.cz
Statins are the most commonly used drugs in patients with dyslipidemia. Among the patients,
a significant inter-individual variability with supposed strong genetic background in statin …
a significant inter-individual variability with supposed strong genetic background in statin …
Pharmacogenetics of statins treatment: Efficacy and safety
ZW Guan, KR Wu, R Li, Y Yin, XL Li… - Journal of Clinical …, 2019 - Wiley Online Library
What is known and objective Statins are widely used worldwide in the prevention and
treatment of coronary atherosclerotic heart disease and ischaemic stroke. However, in …
treatment of coronary atherosclerotic heart disease and ischaemic stroke. However, in …
Pharmacogenetic foundations of therapeutic efficacy and adverse events of statins
Background: In the era of precision medicine, more attention is paid to the search for
predictive markers of treatment efficacy and tolerability. Statins are one of the classes of …
predictive markers of treatment efficacy and tolerability. Statins are one of the classes of …
Genetic Determinants of Response to Statins in Cardiovascular Diseases
G Ghorbannezhad, S Mehrabadi… - Current Cardiology …, 2024 - ingentaconnect.com
Despite extensive efforts to identify patients with cardiovascular disease (CVD) who could
most benefit from the treatment approach, patients vary in their benefit from therapy and …
most benefit from the treatment approach, patients vary in their benefit from therapy and …