Background T cell immunoglobulin-3 (TIM-3) has been established as a negative regulatory
molecule and plays a critical role in immune tolerance. TIM-3 is upregulated in exhausted …

T cell immunoglobulin-and mucin-domain-containing molecule-3 (Tim-3) has been shown to
play an important role in mediating NK-cell function in human diseases. However, the …

Tim-3, a member of the novel Tim (T cell immunoglobulin and mucin domain) family, has
been reported to negatively regulate the immune responses against viral infection and had …

T-cell immunoglobulin–and mucin domain-3–containing molecule 3 (TIM-3) is a membrane
protein expressed in various kinds of immune cells and plays a pivotal role in immune …

Regulatory T cells (Treg cells) are critical mediators of self-tolerance, but they can also limit
effective anti-tumor immunity. Although under homeostasis a small fraction of Treg cells in …

Tim-3 (T cell immunoglobulin and mucin domain 3), belonging to the member of the novel
Tim family, has been confirmed that it plays a critical negative role in regulating the immune …

Background T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and
plays a crucial part in tumor-induced immune suppression. However, the mechanism of …

Aim: To investigate the clinical significance of Tim-3 (T-cell immunoglobulin-and mucin-
domain-containing molecule 3) expression in natural killer (NK) cells from patients with …

T-cell exhaustion represents a progressive loss of T-cell function. The inhibitory receptor PD-
1 is known to negatively regulate CD8+ T cell responses directed against tumor antigen, but …

T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates
innate and adaptive immunity in cancer. To identify the mechanisms of Tim-3 in cancer …