Minocycline has been implicated in the treatment for multiple diseases in the nervous
system for its neuroprotective properties. However, the mechanism by which minocycline …

Although it is known that isoflurane exposure or surgery leads to post‐operative cognitive
dysfunction in aged rodents, there are few clinical interventions and treatments available to …

Postoperative cognitive dysfunction (POCD), an important postoperative neurological
complication, is very common and has an elevated incidence in elderly patients …

Postoperative cognitive dysfunction (POCD) is a severe neurological sequela that occurs in
individuals who have undergone anesthesia and surgery, especially in the geriatric surgical …

Minocycline has been demonstrated to exert neuroprotective effects in various experimental
models. In the present study, we investigated the mechanisms underlying the protective …

Postoperative cognitive dysfunction (POCD) is a clinical phenomenon characterized by
cognitive deficits in patients after anesthesia and surgery, especially in geriatric surgical …

Objective Minocycline, a semisynthetic tetracycline-derived antibiotic, has various
pharmacological effect such as anti-inflammatory, anti-oxidative stress, and anti-apoptotic …

Tetrandrine is a bisbenzylisoquinoline alkaloid extracted from Stephania tetrandra, a
traditional Chinese herbal medicine, which has been observed to exert anti‑inflammatory …

Abstract Postoperative Cognitive Dysfunction (POCD) is a neurological disorder of
unconsciousness due to cognitive regression after surgical anesthesia. However, the …

Rationale The role of glial cells, especially microglia and astrocytes, in neuroinflammation
and cognition has been studied intensively. Lipopolysaccharide (LPS), a commonly used …