Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …

Abstract Background and Objectives Meropenem is frequently used for the treatment of
severe bacterial infections in critically ill patients. Because critically ill patients are more …

Effective antibiotic dosing is vital for therapeutic success in critically ill patients. This work
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …

Introduction The purpose of this study was to explore factors influencing meropenem
pharmacokinetics (PKs) in critically ill patients by developing a population PK model and to …

Objectives Meropenem pharmacokinetics (PK) may be altered in septic critically ill patients
with complicated intra-abdominal infections (cIAI) and pneumonia. We aimed to evaluate the …

Purpose This study aimed to investigate the pharmacokinetics and target attainment of
meropenem and compare the effect of meropenem dosing regimens in critically ill patients …

Abstract Background Several population pharmacokinetic (PopPK) models for meropenem
dosing in ICU patients are available. It is not known to what extent these models can predict …

Population pharmacokinetic analyses can be applied to predict optimized dosages for
individual patients. The aim of this study was to compare the prediction performance of the …

Purpose This study aimed to develop a population pharmacokinetic (PPK) model for
meropenem to optimize dosing regimens for critically ill patients with pulmonary infection …

Purpose In critically ill patients treated with meropenem, the proposed pharmacokinetics/
pharmacodynamics (PK/PD) efficacy index is to keep the free drug concentration 4–5 times …