Structural basis for recognition of AU-rich element RNA by the HuD protein

X Wang, TM Tanaka Hall - Nature structural biology, 2001 - nature.com
Hu proteins bind to adenosine-uridine (AU)-rich elements (AREs) in the 3′ untranslated
regions of many short-lived mRNAs, thereby stabilizing them. Here we report the crystal …

HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA

S Park, DG Myszka, M Yu, SJ Littler… - Molecular and cellular …, 2000 - Taylor & Francis
Human neuron-specific RNA-binding protein HuD belongs to the family of Hu proteins and
consists of two N-terminal RNA recognition motifs (RRM1 and-2), a hinge region, and a C …

The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding

H Wang, F Zeng, Q Liu, H Liu, Z Liu, L Niu… - … Section D: Biological …, 2013 - scripts.iucr.org
Human RNA-binding protein (HuR), a ubiquitously expressed member of the Hu protein
family, plays an important role in mRNA degradation and has been implicated as a key post …

Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM

N Ripin, J Boudet, MM Duszczyk… - Proceedings of the …, 2019 - National Acad Sciences
Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–
rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3 …

Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences

EJ Fialcowitz-White, BY Brewer, JD Ballin… - Journal of Biological …, 2007 - ASBMB
The RNA-binding factor HuR is a ubiquitously expressed member of the Hu protein family
that binds and stabilizes mRNAs containing AU-rich elements (AREs). Hu proteins share a …

Complex formation of the neuron‐specific ELAV‐like Hu RNA‐binding proteins

K Kasashima, E Sakashita, K Saito… - Nucleic acids …, 2002 - academic.oup.com
Hu proteins are RNA‐binding proteins that are the vertebrate homologs of Drosophila ELAV,
and are implicated in stabilization or enhanced translation of specific mRNAs with AU‐rich …

Characterization of the interaction between neuronal RNA-binding protein HuD and AU-rich RNA

S Park-Lee, S Kim, IA Laird-Offringa - Journal of Biological Chemistry, 2003 - ASBMB
Hu proteins have been shown to bind to AU-rich elements (AREs) in the 3′-untranslated
region of unstable mRNAs. They can thereby inhibit the decay of labile transcripts by …

Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization

CYA Chen, N Xu, AB Shyu - Molecular and cellular biology, 2002 - Taylor & Francis
Human RNA-binding protein HuR, a nucleocytoplasmic shuttling protein, is a ubiquitously
expressed member of the family of Hu proteins, which consist of two N-terminal RNA …

Sequence requirements for RNA binding by HuR and AUF1

A Barker, MR Epis, CJ Porter… - The journal of …, 2012 - academic.oup.com
The stability of RNAs bearing AU-rich elements in their 3′-UTRs, and thus the level of
expression of their protein products, is regulated by interactions with cytoplasmic RNA …

[HTML][HTML] Overexpression of HuR, a nuclear–cytoplasmic shuttling protein, increases the in vivo stability of ARE‐containing mRNAs

XC Fan, JA Steitz - The EMBO journal, 1998 - embopress.org
The messenger RNAs of many proto‐oncogenes, cytokines and lymphokines are targeted
for rapid degradation through AU‐rich elements (AREs) located in their 3′ untranslated …