In chronic hepatitis C (CHC), characterized by exhaustion of T-cell function, increased
frequencies of double-positive (DP)(CD4+ CD8+) cells are present in peripheral blood. We …

Chronic hepatitis C virus (HCV) infection is characterized by increased proportion of CD4+
CD8+ double positive (DP) T cells, but their role in this infection is unclear. In chronic …

During chronic hepatitis C virus (HCV) infection, both CD4+ and CD8+ T-cells become
functionally exhausted, which is reflected by increased expression of programmed cell death …

Background and Aims During chronic hepatitis C virus (HCV) infection, CD8+ T-cells
become functionally exhausted, undergoing progressive phenotypic changes, ie …

Abstract CD8+ CD28− regulatory T cells (Tregs) play important roles in chronic viral
infections. Programmed death 1 (PD-1) is highly expressed on hepatitis C virus (HCV) …

There is increasing interest in the role of T cell exhaustion and it is well known that the
natural history of chronic hepatitis C virus infection (HCV) is modulated by CD8+ T cell …

Hepatitis C virus (HCV)-specific CD4+ and CD8+ T cells are key to successful viral
clearance in HCV disease. Accumulation of exhausted HCV-specific T cells during chronic …

ABSTRACT A majority of patients infected with hepatitis C virus (HCV) do not sustain an
effective T-cell response, and viremia persists. The mechanism leading to failure of the HCV …

Chronic hepatitis C virus (HCV) infection is associated with impaired proliferative, cytokine,
and cytotoxic effector functions of HCV-specific CD8+ T cells that probably contribute …

Methods Lymphocytes from peripheral blood were obtained from 108 patients with CHC and
43 healthy subjects. Immunophenotyping, functional assays, T‐cell receptor (TCR) …