Simple Summary Maintenance of telomeres is a fundamental step in human carcinogenesis
and is primarily regulated by telomerase and the human telomerase reverse transcriptase …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a
RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of …

The maintenance of specialized nucleoprotein structures termed telomeres is essential for
chromosome stability. Without new synthesis of telomeres at chromosome ends the …

Telomeres are located at the ends of chromosomes and protect them from degradation.
Suppressing the activity of telomerase, a telomere‑synthesizing enzyme, and maintaining …

Telomerase activity is dependent on the expression of 2 main core component genes,
hTERT, which encodes the catalytic component and hTR (also called TERC), which …

The intimate connection between telomerase regulation and human disease is now well
established. The molecular basis for telomerase regulation is highly complex and entails …

Activation of telomerase is a critical step in the development of about 85% of human
cancers. Levels of Tert, which encodes the reverse transcriptase subunit of telomerase, are …

Telomere maintenance is a hallmark of human cancer that enables replicative immortality.
Most cancer cells acquire telomere maintenance by telomerase activation through …

Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …