In recent years, a number of studies have alluded to the importance of the intestinal
microflora in controlling whole-body metabolic homeostasis and organ physiology. In …

Intestinal microbiota metabolism of choline and phosphatidylcholine produces
trimethylamine (TMA), which is further metabolized to a proatherogenic species …

L-carnitine, a nutrient in red meat, was recently reported to accelerate atherosclerosis via a
metaorganismal pathway involving gut microbial trimethylamine (TMA) formation and host …

Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …

BACKGROUND. l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis
in mice via gut microbiota–dependent formation of trimethylamine (TMA) and trimethylamine …

Background Recent studies in animal models have shown a link between ingestion of
dietary phosphatidylcholine (PC), choline, l-carnitine and cardiovascular risk. Intestinal …

Aims Carnitine and choline are major nutrient precursors for gut microbiota-dependent
generation of the atherogenic metabolite, trimethylamine N-oxide (TMAO). We performed …

Our group recently discovered that certain dietary nutrients possessing a trimethylamine
(TMA) moiety, namely choline/phosphatidylcholine and L-carnitine, participate in the …

Background Intestinal microbiota have been found to be linked to cardiovascular disease via
conversion of the dietary compounds choline and carnitine to the atherogenic metabolite …

Background: Effects of animal source foods (ASF) on atherosclerotic cardiovascular disease
(ASCVD) and underlying mechanisms remain controversial. We investigated prospective …