Neurocognitive impairment (NCI) is one of the most relevant clinical manifestations of
multiple sclerosis (MS). The profile of NCI and the structural and functional changes in the …

The central nervous system (CNS) has long been considered an immune‐privileged site,
with minimal interaction between immune cells, particularly of the adaptive immune system …

Neurodegenerative diseases are closely related to inflammatory and autoimmune events,
suggesting that the dysregulation of the immune system is a key pathological factor. Both …

The impact of the immune system on the etiopathogenesis of neurodegenerative diseases,
including Alzheimer's disease, is a rapidly growing area of investigation. Evidence from …

Alzheimer disease (AD) is the most prevalent form of dementia although the underlying
cause (s) remains unknown at this time. However, neuroinflammation is believed to play an …

Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disorder
of the CNS. The etiology of MS remains unknown. However, it is well established that …

CD4+ T cells orchestrate innate and adaptive immunity. In the central nervous system they
modulate immune responses including cell trafficking and glial neuroregulatory functions …

Pathogenic mechanisms of T cells in several central nervous system (CNS) disorders are
well-established. However, more recent studies have uncovered compelling beneficial roles …

Traditionally, multiple sclerosis (MS) was considered to be a CD4 T cell-mediated CNS
autoimmunity, compatible with experimental autoimmune encephalitis model, which can be …

Autoreactive CD4+ T cells, which target antigens in central nervous system (CNS) myelin,
are widely believed to play a critical role in the pathogenesis of multiple sclerosis (MS) in …