Inhibition of oxidative stress and NLRP3 inflammasome by Saikosaponin-d alleviates acute liver injury in carbon tetrachloride-induced hepatitis in mice
Y Chen, R Que, L Lin, Y Shen… - International Journal of …, 2020 - journals.sagepub.com
NLRP3 inflammasome activation results in severe liver inflammation and injury.
Saikosaponin-d (SSd) possesses anti-inflammatory and hepatoprotective effects. This study …
Saikosaponin-d (SSd) possesses anti-inflammatory and hepatoprotective effects. This study …
[HTML][HTML] Saikosaponin‑d alleviates carbon‑tetrachloride induced acute hepatocellular injury by inhibiting oxidative stress and NLRP3 inflammasome activation in the …
L Lin, R Que, Y Shen, Y Chen… - Molecular medicine …, 2018 - spandidos-publications.com
Saikosaponin‑d (SSd) the primary active component of triterpene saponin derived from
Bupleurum falcatum L., possesses anti‑inflammatory and antioxidant properties. The present …
Bupleurum falcatum L., possesses anti‑inflammatory and antioxidant properties. The present …
[HTML][HTML] Saikosaponin d alleviates liver fibrosis by negatively regulating the ROS/NLRP3 inflammasome through activating the ERβ pathway
K Zhang, L Lin, Y Zhu, N Zhang, M Zhou… - Frontiers in …, 2022 - frontiersin.org
Background and aims: Saikosaponin d (SSd) has a steroidal structure and significant anti-
inflammatory effects. The purpose of this study was to explore the mechanism underlying …
inflammatory effects. The purpose of this study was to explore the mechanism underlying …
[HTML][HTML] Sophocarpine attenuates septic liver injury through suppression of the NLRP3 inflammasome via autophagy‑mediated degradation
N Hou, X Dai, W Lu, H Yang, H Yu… - Experimental and …, 2020 - spandidos-publications.com
Septic liver injury remains a challenge in sepsis treatment. Nucleotide‑binding
oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) …
oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) …
Saikosaponin a ameliorates lipopolysaccharide and d‑galactosamine-induced liver injury via activating LXRα
Y Zhu, X Chen, X Rao, C Zheng, X Peng - International …, 2019 - Elsevier
Saikosaponin a (SSa), one of the major active components of Bupleurum falcatum, has
antioxidant and anti-inflammatory pharmacological properties. However, the effects of SSa …
antioxidant and anti-inflammatory pharmacological properties. However, the effects of SSa …
[HTML][HTML] Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats
SS Dang, BF Wang, YA Cheng, P Song… - World journal of …, 2007 - ncbi.nlm.nih.gov
AIM: To investigate the suppressive effect of saikosaponin-d (SSd) on hepatic fibrosis in rats
induced by CCl 4 injections in combination with alcohol and high fat, low protein feeding …
induced by CCl 4 injections in combination with alcohol and high fat, low protein feeding …
Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome …
X Liu, T Wang, X Liu, L Cai, J Qi, P Zhang… - International …, 2016 - Elsevier
Biochanin A, an isoflavone existed in red clover and peanuts, has been reported to possess
a wide spectrum of pharmacological activities, such as anti-inflammatory and antioxidant …
a wide spectrum of pharmacological activities, such as anti-inflammatory and antioxidant …
Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling
Overdose of acetaminophen (APAP) can cause acute liver injury that is sometimes fatal,
requiring efficient pharmacological intervention. The traditional Chinese herb Bupleurum …
requiring efficient pharmacological intervention. The traditional Chinese herb Bupleurum …
[HTML][HTML] The ameliorative effects of saikosaponin in thioacetamide-induced liver injury and non-alcoholic fatty liver disease in mice
GR Chang, WL Lin, TC Lin, HJ Liao, YW Lu - International journal of …, 2021 - mdpi.com
Liver disorders are a major health concern. Saikosaponin-d (SSd) is an effective active
ingredient extracted from Bupleurum falcatum, a traditional Chinese medicinal plant, with …
ingredient extracted from Bupleurum falcatum, a traditional Chinese medicinal plant, with …
Salidroside protects mice against CCl4-induced acute liver injury via down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome activation
X Zhang, G Kuang, J Wan, R Jiang, L Ma… - International …, 2020 - Elsevier
Salidroside (Sal), a natural phenolic compound isolated from Rhodiola sachalinensis, has
been utilized as anti-inflammatory and antioxidant for centuries, however, its effects against …
been utilized as anti-inflammatory and antioxidant for centuries, however, its effects against …