NLRP3 inflammasome activation results in severe liver inflammation and injury.
Saikosaponin-d (SSd) possesses anti-inflammatory and hepatoprotective effects. This study …

Saikosaponin‑d (SSd) the primary active component of triterpene saponin derived from
Bupleurum falcatum L., possesses anti‑inflammatory and antioxidant properties. The present …

Background and aims: Saikosaponin d (SSd) has a steroidal structure and significant anti-
inflammatory effects. The purpose of this study was to explore the mechanism underlying …

Septic liver injury remains a challenge in sepsis treatment. Nucleotide‑binding
oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) …

Saikosaponin a (SSa), one of the major active components of Bupleurum falcatum, has
antioxidant and anti-inflammatory pharmacological properties. However, the effects of SSa …

AIM: To investigate the suppressive effect of saikosaponin-d (SSd) on hepatic fibrosis in rats
induced by CCl 4 injections in combination with alcohol and high fat, low protein feeding …

Biochanin A, an isoflavone existed in red clover and peanuts, has been reported to possess
a wide spectrum of pharmacological activities, such as anti-inflammatory and antioxidant …

Overdose of acetaminophen (APAP) can cause acute liver injury that is sometimes fatal,
requiring efficient pharmacological intervention. The traditional Chinese herb Bupleurum …

Liver disorders are a major health concern. Saikosaponin-d (SSd) is an effective active
ingredient extracted from Bupleurum falcatum, a traditional Chinese medicinal plant, with …

Salidroside (Sal), a natural phenolic compound isolated from Rhodiola sachalinensis, has
been utilized as anti-inflammatory and antioxidant for centuries, however, its effects against …