Replication forks terminate at TERs and telomeres. Forks that converge or encounter
transcription generate topological stress. Combining genetics, genomics, and transmission …

Transcription hinders replication fork progression and stability. The ATR checkpoint and
specialized DNA helicases assist DNA synthesis across transcription units to protect …

DNA replication and RNA transcription compete for the same substrate during S phase.
Cells have evolved several mechanisms to minimize such conflicts. Here, we identify the …

Chromosome replication initiates at multiple replicons and terminates when forks converge.
In E. coli, the Tus-TER complex mediates polar fork converging at the terminator region, and …

Genomic instability associated with DNA replication stress is linked to cancer and genetic
pathologies in humans. If not properly regulated, replication stress, such as fork stalling and …

Replication fork reversal is a global response to replication stress in mammalian cells, but
precisely how it occurs remains poorly understood. Here, we show that, upon replication …

Telomere maintenance critically depends on the distinct activities of telomerase, which adds
telomeric repeats to solve the end replication problem, and RTEL1, which dismantles DNA …

Hard-to-replicate regions of chromosomes (eg, pericentromeres, centromeres, and
telomeres) impede replication fork progression, eventually leading, in the event of …

Uncoordinated clashes between replication forks and transcription cause replication stress
and genome instability, which are hallmarks of cancer and neurodegeneration. Here, we …

Topological stress can cause converging replication forks to stall during termination of
vertebrate DNA synthesis. However, replication forks ultimately overcome fork stalling …