[HTML][HTML] The genetic basis of onset age in schizophrenia: evidence and models

N Zhan, PC Sham, HC So, SSY Lui - Frontiers in genetics, 2023 - frontiersin.org
Schizophrenia is a heritable neurocognitive disorder affecting about 1% of the population,
and usually has an onset age at around 21–25 in males and 25–30 in females. Recent …

[HTML][HTML] Common genetic variants contribute to heritability of age at onset of schizophrenia

E Sada-Fuente, S Aranda, S Papiol… - Translational …, 2023 - nature.com
Schizophrenia (SCZ) is a complex disorder that typically arises in late adolescence or early
adulthood. Age at onset (AAO) of SCZ is associated with long-term outcomes of the disease …

Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history

SE Bergen, CT O'Dushlaine, PH Lee, AH Fanous… - Schizophrenia …, 2014 - Elsevier
Schizophrenia is a genetically and clinically heterogeneous disorder. Genetic risk factors for
the disorder may differ between the sexes or between multiply affected families compared to …

Why does age of onset predict clinical severity in schizophrenia? A multiplex extended pedigree study

CW Musket, SS Kuo, PE Rupert… - American Journal of …, 2020 - Wiley Online Library
Schizophrenia has substantial variation in symptom severity, course of illness, and overall
functioning. Earlier age of onset (AOO) is consistently associated with negative outcomes …

Genome‐wide association analysis of age at onset in schizophrenia in a European‐American sample

KS Wang, X Liu, Q Zhang, N Aragam… - American Journal of …, 2011 - Wiley Online Library
We performed a genome‐wide association analysis to identify genetic variants influencing
age at onset (AAO) and examine gene× gender interactions for AAO in schizophrenia (SCZ) …

[HTML][HTML] Genome wide association study identifies four loci for early onset schizophrenia

S Guo, J Liu, W Li, Y Yang, L Lv, X Xiao, M Li… - Translational …, 2021 - nature.com
Early onset schizophrenia (EOS, defined as first onset of schizophrenia before age 18) is a
rare form of schizophrenia (SCZ). Though genome-wide association studies (GWASs) have …

[HTML][HTML] Genetic loci associated with an earlier age at onset in multiplex schizophrenia

AL Woolston, PC Hsiao, PH Kuo, SH Wang, YJ Lien… - Scientific reports, 2017 - nature.com
An earlier age at onset (AAO) has been associated with greater genetic loadings in
schizophrenia. This study aimed to identify modifier loci associated with an earlier AAO of …

The significance of age of onset for schizophrenia

LE DeLisi - Schizophrenia bulletin, 1992 - academic.oup.com
Age of onset is the single most important characteristic of schizophrenia that could yield
clues to its origin. To identify the age of onset, however, the onset of the pathological …

Advanced paternal age and early onset of schizophrenia in sporadic cases: not confounded by parental polygenic risk for schizophrenia

SH Wang, PC Hsiao, LL Yeh, CM Liu, CC Liu… - Biological …, 2019 - Elsevier
Background Whether paternal age effect on schizophrenia is a causation or just an
association due to confounding by selection into late parenthood is still debated. We …

Heritability of age of onset of psychosis in schizophrenia

E Hare, DC Glahn, A Dassori… - American Journal of …, 2010 - Wiley Online Library
Schizophrenia is a genetically complex illness with heterogeneous clinical presentation,
including variable age of onset. In this study, the heritability, or proportion of variation in age …